Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-28

Study Completion Date

2024-10-31

Brief Summary

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Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.

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Detailed Description

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Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).

Conditions

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Cognition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Acute effects of oxygen on memory testing in healthy adult volunteers

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Air First

All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.

Group Type OTHER

Cross Over Assignment Supplemental Oxygen and Supplemental Air

Intervention Type DEVICE

Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing "supplemental air" (in an order randomly assigned).

Oxygen First

All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.

Group Type OTHER

Cross Over Assignment Supplemental Oxygen and Supplemental Air

Intervention Type DEVICE

Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing "supplemental air" (in an order randomly assigned).

Interventions

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Cross Over Assignment Supplemental Oxygen and Supplemental Air

Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing "supplemental air" (in an order randomly assigned).

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Subjects are intended to represent "healthy adults." Patients will include a mix of self-reported gender and ethnic/racial identification.

1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Adult (aged 22+)

Exclusion Criteria

* Patients who self-report diagnosis of respiratory-related conditions will be excluded.
* Subjects with a known polyvinyl chloride (PVC) allergy will be excluded, due to potential use of a standard, PVC-based cannula in the study.

Minimum Eligible Age

22 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes