Balance Control and Recovery in Diabetes Peripheral Neuropathy
NCT ID: NCT06544876
Last Updated: 2024-08-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2023-09-12
2028-08-31
Brief Summary
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Aim 1: Determine muscle activity and balance control during a sit-to-stand in adults age above 50 with and without diabetic peripheral neuropathy.
Aim 2: Assess local balance recovery and latency responses to lateral surface perturbation during quiet standing.
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Detailed Description
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DPN typically affects more distal peripheral nerve branches, resulting in sensory loss. DPN causes axonal damage and leads to a loss of muscle strength. These degenerative effects significantly contribute to fall risks and feelings of instability.
Falls most commonly occur during transitional tasks such as the sit-to-stand (STS) and stand-to-sit (StandTS). The overall objective of this study to assess the effects of DPN on balance control and muscle activity during transitional tasks (STS and StandTS) and during lateral perturbation while standing.
Study procedures:
1. Measures of body weight, height, and limb diameter and measuring including leg length, knee width, elbow width, wrist width, and hand thickness.
2. Measures of sensation of the big toe and heel area for both legs.
3. Surface sensors will be placed on the leg muscles using non-allergic double adhesive tape.
4. Participants will sit down and stand up on a chair with adjustable height.
5. Then, participants will be asked to stand on a treadmill holding a ruler. The treadmill will slightly move left and right, and the muscle activity and balance control will be evaluated.
6. Finally, muscle strength of the legs' muscles will be collected.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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healthy younger adult
sit-to-stand
test for balance during movement from sitting to standing
stand to sit
test for balance during movement from standing to sitting
standing perturbation
test for balance recovery following perturbation
MRI of sciatic nerve
measure of peripheral nerve diameter
Healthy older adult
sit-to-stand
test for balance during movement from sitting to standing
stand to sit
test for balance during movement from standing to sitting
standing perturbation
test for balance recovery following perturbation
MRI of sciatic nerve
measure of peripheral nerve diameter
older adult with diabetic peripheral neuropathy
sit-to-stand
test for balance during movement from sitting to standing
stand to sit
test for balance during movement from standing to sitting
standing perturbation
test for balance recovery following perturbation
MRI of sciatic nerve
measure of peripheral nerve diameter
Interventions
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sit-to-stand
test for balance during movement from sitting to standing
stand to sit
test for balance during movement from standing to sitting
standing perturbation
test for balance recovery following perturbation
MRI of sciatic nerve
measure of peripheral nerve diameter
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Partial amputation
* Have experience of Stroke
* Painful neuropathy
* Inability to stand or walk independently
50 Years
99 Years
ALL
Yes
Sponsors
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Lisa Griffin
OTHER
Responsible Party
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Lisa Griffin
Associate Professor
Locations
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The University of Texas at Austin
Austin, Texas, United States
Countries
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Facility Contacts
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Other Identifiers
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STUDY00001512
Identifier Type: -
Identifier Source: org_study_id
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