Clinical Retrospective Study Analysis of Postoperative Complications Following Hepatectomy

NCT ID: NCT06532214

Last Updated: 2024-08-01

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 2000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-01-01
• Study Completion Date: 2025-12-31

Brief Summary

Hepatectomy is a crucial surgical method for treating liver diseases such as liver cancer, hepatic hemangiomas, and biliary stones. Although hepatectomy has achieved significant therapeutic effects, postoperative complications remain an inevitable issue. Complications following hepatectomy include liver failure, hepatic vascular thrombosis, wound infection at the hepatic incision, and bile leakage, among others. These complications pose a serious threat to patients' health and life, and also increase the waste of medical resources and the cost of treatment. Currently, research on postoperative complications of hepatectomy mainly focuses on small sample studies from a single center, and most studies only focus on a specific complication, lacking comprehensive and systematic analysis. Therefore, it is necessary to conduct a retrospective study analysis of complications related to hepatectomy to more comprehensively and objectively understand the incidence, risk factors, prevention, and treatment of postoperative complications, providing clinical doctors with more scientific treatment plans and guidance.

Conditions

Liver Failure; Liver Dysfunction

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

PHLF/NPHLF

PHLF:Post-hepatectomy liver failure,PHLF is commonly diagnosed and classified according to the criteria of the International Study Group for Liver Surgery (ISGLS), utilizing markers of liver function measured on or after postoperative day 5 (POD5). NPHLF:Patients who did not experience liver failure following hepatectomy.

International Study Group for Liver Surgery (ISGLS)

Intervention Type: DIAGNOSTIC_TEST

According to the ISGLS criteria, the patient was judged to have liver failure and further analysis

Liver Cirrhosis/No Liver Cirrhosis

Whether the patient has cirrhosis

No interventions assigned to this group

Interventions

International Study Group for Liver Surgery (ISGLS)

According to the ISGLS criteria, the patient was judged to have liver failure and further analysis

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• 1. Patients aged 18-80 years 2.Patients who underwent liver resection surgery at the participating centers

Exclusion Criteria

1. Prior cancer treatments such as transarterial chemoembolization, ablation, or targeted therapy.

2. Repeat liver resection surgeries.

3. Presence of other malignancies.

4. Concurrent end-stage diseases including active infections, respiratory failure, decompensated heart failure, and autoimmune disease exacerbations.

5. Inadequate clinical data availability in medical records.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Nanfang Hospital, Southern Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Nanfang Hospital

Guangzhou, Guangdong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Kai Wang

Role: CONTACT

kaiwang@smu.edu.cn

13710574386

Facility Contacts

kai wang

Role: primary

kaiwang@smu.edu.cn

13710574386

References

Wang K, Yang Q, Li K, Tang S, Zhang B, Liao X, Du S, Fu W, Li Z, Chen H, Xie H, Huang P, Li J, Wang Q, Liu H, Huang Z, Heng PA, Wan X, Li C, Si W. Learning-based early detection of post-hepatectomy liver failure using temporal perioperative data: a nationwide multicenter retrospective study in China. EClinicalMedicine. 2025 May 6;83:103220. doi: 10.1016/j.eclinm.2025.103220. eCollection 2025 May.

Reference Type: DERIVED

PMID: 40630620 (View on PubMed)

Other Identifiers

NFEC-2023-245

Identifier Type: -

Identifier Source: org_study_id