Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

142 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-03

Study Completion Date

2026-05-03

Brief Summary

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To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors. Having such a method at our disposal would enable us to better assess the risk to develop those defects and will help us provide new prevention and treatment strategies to ensure a healthy oral development.

The aims of this study are :

* Assess the caries risk in childhood cancer survivors compared with a control group.
* Assess the dental development defects risk in childhood cancer survivors compared with a control group.

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Detailed Description

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This will be an international study comparing the Childhood Cancer Survivors (CCS) and a control group.

A questionnaire will be provided to the patients to gather information. A standard of care dental examination will then take place in a dental office in the Cliniques Universitaires Saint-Luc. We also collect medical data to complete the files.

Conditions

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Chemotherapy Effect Dental Caries Malocclusion Childhood Cancer Tooth Defect

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Interventionnal study, cohort study

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Cancer survivor

Group Type EXPERIMENTAL

Clinical and radiographic dental examination

Intervention Type DIAGNOSTIC_TEST

complete clinical oral examination + intra-oral and panoramic x-rays

Control

Group Type ACTIVE_COMPARATOR

Clinical and radiographic dental examination

Intervention Type DIAGNOSTIC_TEST

complete clinical oral examination + intra-oral and panoramic x-rays

Interventions

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Clinical and radiographic dental examination

complete clinical oral examination + intra-oral and panoramic x-rays

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* age below 10 at cancer diagnosis (for the CCS group).
* Chemotherapy must have been used to treat the patient (For the CCS group).
* The patient is 12 years old or older at the time of the follow-up appointment of the present study

Exclusion Criteria

* A patient who was diagnosed and treated after 10 years old.
* Patient below 12 years old at time of study recruitment
* Patients with syndrome or diseases that involve teeth impairment\*
* Pregnant patient
* Refusal or inaptitude to undergo dental and radiographic examination

Minimum Eligible Age

12 Years

Maximum Eligible Age

36 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No