Active Health Education to Increase HPV Vaccine Coverage in Youth: A Stepped-wedge, Cluster, and Randomized Trial

NCT ID: NCT06513494

Last Updated: 2025-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

5000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-24

Study Completion Date

2026-12-01

Brief Summary

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This study aims to evaluate the impact of active health education methodologies on increasing adherence to the HPV vaccine among schoolchildren. The project will involve 196 schools across Brazil, encompassing a total of 5,000 students.

A stepped-wedge implementation design will be applied, with clusters being randomized every two months to one of four interventions.

Each intervention will be implemented in 48 schools.

Detailed Description

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The adherence to the HPV vaccine among young people has declined recently, particularly in Brazil. While previous studies have shown that interventions such as text messaging can increase vaccination coverage, there is still a lack of robust data on the effectiveness of direct interventions in school populations using active health education methods. This study aims to evaluate the impact of active health education methodologies on increasing adherence to the HPV vaccine among schoolchildren.

The project will involve 80 schools across Brazil, including a total of 5,000 students. These schools will be randomized into clusters of five.

The study will apply a stepped-wedge implementation design, with clusters being randomized every two months to one of four interventions:

Education for students and teachers training + Basic Health Unit action in schools Education for students without teachers training + Basic Health Unit action in schools Only Basic Health Unit activities Usual control

Conditions

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Vaccine Refusal Vaccine Hesitancy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Stepped-wedge, Cluster, and Randomized trial
Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Active Students Education plus Teacher Training

Clusters will perform active training for both teachers and students.

Group Type EXPERIMENTAL

Active Students Education plus Teacher Training

Intervention Type BEHAVIORAL

The teacher undergoes 30 hours of self-instructional training on vaccination through an online platform tailored for the relevant age group. Additionally, students receive active vaccinations and health education over two months

Active Students Education

Clusters will perform active training for only students.

Group Type EXPERIMENTAL

Active Students Education

Intervention Type BEHAVIORAL

Students receive active vaccinations and health education over two months.

Basic Health Unit Active Orientation

Clusters will receive a nurse-led orientation session on vaccination for students in schools.

Group Type EXPERIMENTAL

Basic Health Unit Active Orientation

Intervention Type BEHAVIORAL

Nurses from basic health units will conduct an active orientation session at schools about vaccination for students.

Usual care

No project interventions will be carried out.

Group Type OTHER

Usual care

Intervention Type OTHER

No project interventions will be carried out.

Interventions

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Active Students Education plus Teacher Training

The teacher undergoes 30 hours of self-instructional training on vaccination through an online platform tailored for the relevant age group. Additionally, students receive active vaccinations and health education over two months

Intervention Type BEHAVIORAL

Active Students Education

Students receive active vaccinations and health education over two months.

Intervention Type BEHAVIORAL

Basic Health Unit Active Orientation

Nurses from basic health units will conduct an active orientation session at schools about vaccination for students.

Intervention Type BEHAVIORAL

Usual care

No project interventions will be carried out.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Students of both sexes aged 9 to 14 years old.


* The school has enrolled students aged 9 to 14 years old.

Exclusion Criteria

* Students with a complete HPV vaccination (two doses) received.

Criteria for Clusters


* Schools that do not have students aged between 9 and 14;
* Schools that provided only distance education
Minimum Eligible Age

9 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ministry of Health, Brazil

OTHER_GOV

Sponsor Role collaborator

Hospital Israelita Albert Einstein

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Prof. Henrique A Fonseca, PhD

Role: STUDY_CHAIR

Academic Research Organization - Hospital Israelita Albert Einstein

Prof. Luiz V Rizzo, PhD

Role: STUDY_CHAIR

Academic Research Organization - Hospital Israelita Albert Einstein

Locations

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Cel Filemon Fernandes Teles

Crato, Ceará, Brazil

Site Status RECRUITING

Dom Vicente de Paula Araujo Matos

Crato, Ceará, Brazil

Site Status RECRUITING

EEIEF Maria Yara de Brito Gonçalves CAIC

Crato, Ceará, Brazil

Site Status RECRUITING

EEIF Antonio Antuérpio Gonzaga de Melo

Crato, Ceará, Brazil

Site Status RECRUITING

EEF José Ferreira Menezes

Juazeiro do Norte, Ceará, Brazil

Site Status RECRUITING

EEF Raimundo Pessoa

Juazeiro do Norte, Ceará, Brazil

Site Status RECRUITING

EEF Zila Belem

Juazeiro do Norte, Ceará, Brazil

Site Status RECRUITING

Emef Mário Da Silva Bem

Juazeiro do Norte, Ceará, Brazil

Site Status RECRUITING

Emef Professora Maria de Lourdes Lopes de Sousa

Juazeiro do Norte, Ceará, Brazil

Site Status RECRUITING

EMEIF Maria Do Socorro Cardoso

Juazeiro do Norte, Ceará, Brazil

Site Status RECRUITING

CED 4 do Guará

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF 04 Ceilandia

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF 2 da estrutural

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF 3 da Estrutural

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF 4 Guará

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF Lobo Guará

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF Santos Dumont

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF Telebrasília

Brasília, Federal District, Brazil

Site Status RECRUITING

CEF Vargem Bonita

Brasília, Federal District, Brazil

Site Status RECRUITING

Cei 02 - Prof João Crisóstomo de Figueiredo

Cuiabá, Mato Grosso, Brazil

Site Status RECRUITING

Ee Ana Maria Do Couto

Cuiabá, Mato Grosso, Brazil

Site Status RECRUITING

Ee Mariana Luiza Moreira

Cuiabá, Mato Grosso, Brazil

Site Status RECRUITING

EE PROFª DIVA HUGUENEY DE SIQUEIRA BASTOS

Cuiabá, Mato Grosso, Brazil

Site Status RECRUITING

EE PROFº RAFAEL RUEDA

Cuiabá, Mato Grosso, Brazil

Site Status RECRUITING

Ee Deputado Milton Figueiredo

Várzea Grande, Mato Grosso, Brazil

Site Status RECRUITING

EE Tancredo de Almeida Neves

Couto de Magalhães de Minas, Minas Gerais, Brazil

Site Status RECRUITING

EM São Judas Tadeu

Couto de Magalhães de Minas, Minas Gerais, Brazil

Site Status RECRUITING

EE Arthur Tibães

Diamantina, Minas Gerais, Brazil

Site Status RECRUITING

EE João Cesar de Oliveira

Diamantina, Minas Gerais, Brazil

Site Status RECRUITING

EE Professor Gabriel Madacaru

Diamantina, Minas Gerais, Brazil

Site Status RECRUITING

EE Professor Leopoldo Miranda

Diamantina, Minas Gerais, Brazil

Site Status RECRUITING

EE Professora Gabriela Neves

Diamantina, Minas Gerais, Brazil

Site Status RECRUITING

Escola Estadual Professora Isabel Motta

Diamantina, Minas Gerais, Brazil

Site Status RECRUITING

EE Felício dos Santos

Felício dos Santos, Minas Gerais, Brazil

Site Status RECRUITING

EM Santo Antônio

Felício dos Santos, Minas Gerais, Brazil

Site Status RECRUITING

EE Dom João Antônio dos Santo

São Gonçalo do Rio Preto, Minas Gerais, Brazil

Site Status RECRUITING

EM Zulma Rocha dos Santos

São Gonçalo do Rio Preto, Minas Gerais, Brazil

Site Status RECRUITING

CE C-M-Ef M Profis Jose Elias da Rocha

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

CE Pe-Ef M Pedro Grzelczaki

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

CE Prof-Ef M Profis Meneleu A Torres

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

CE Prof-Ef M Profis. Joao R V B du Vernay

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EE Profa-Ef Halia T Gruba

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EE-Ef Jesus Divino Operario

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EM Doutor Leopoldo Pinto Rosas

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EM Professora Agenoridas Stadler

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EM Professora Cristiane Levandowski

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EM Professora Zair Santos Nascimento

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EM Professora Zanoni Rogoski

Ponta Grossa, Paraná, Brazil

Site Status RECRUITING

EM Alfredo Monteiro de Seixas

Augusto Corrêa, Pará, Brazil

Site Status RECRUITING

EM Andre Alves

Augusto Corrêa, Pará, Brazil

Site Status RECRUITING

EM Carmem Dilce

Augusto Corrêa, Pará, Brazil

Site Status RECRUITING

EM Manoel Sady

Augusto Corrêa, Pará, Brazil

Site Status RECRUITING

EM Maria Benedita Mota

Augusto Corrêa, Pará, Brazil

Site Status RECRUITING

EM Maria da Conceição Santana

Augusto Corrêa, Pará, Brazil

Site Status RECRUITING

EM Rosa Athayde

Augusto Corrêa, Pará, Brazil

Site Status RECRUITING

EM Edom do Nascimento Pinheiro

Tracuateua, Pará, Brazil

Site Status RECRUITING

EM Elias Ferez Gorayeb

Tracuateua, Pará, Brazil

Site Status RECRUITING

EM Levina de Oliveira Reis

Tracuateua, Pará, Brazil

Site Status RECRUITING

EM Valdemar Pinheiro da Silva

Tracuateua, Pará, Brazil

Site Status RECRUITING

EM Zulmira Guedes

Tracuateua, Pará, Brazil

Site Status RECRUITING

EE Alceu Amoroso Lima

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EE Aldo Fernandes

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EE Djalma Aranha Marinho

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EE Isabel Gondim

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EE Reginaldo Ferreira Neto

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EM Ferreira Itajubá

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EM José Alves Landim

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EM José do Patrocínio Pereira Pinto

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

EM Professora Lourdes Godeiro

Natal, Rio Grande do Norte, Brazil

Site Status RECRUITING

Cem Iii Irmã Maria Teresa Parodi

Boa Vista, Roraima, Brazil

Site Status RECRUITING

Ee Fagundes Varela

Boa Vista, Roraima, Brazil

Site Status RECRUITING

Ee Jesus Nazareno de Souza Cruz

Boa Vista, Roraima, Brazil

Site Status RECRUITING

Em Valdemarina Normando Martins

Boa Vista, Roraima, Brazil

Site Status RECRUITING

Cem José Aureliano Da Costa

Cantá, Roraima, Brazil

Site Status RECRUITING

Em Tia Ercília

Cantá, Roraima, Brazil

Site Status RECRUITING

Cem Maria Mariselma de Oliveira Cruz

Mucajaí, Roraima, Brazil

Site Status RECRUITING

Ee Vereador Francisco Pereira Lima

Mucajaí, Roraima, Brazil

Site Status RECRUITING

Em Irmã Leonilde Dal Pós

Mucajaí, Roraima, Brazil

Site Status RECRUITING

Em Jesus de Nazaré

Mucajaí, Roraima, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Soraya S Cruz

Role: CONTACT

55 11 2151-1233 ext. ARO

Henrique A Fonseca

Role: CONTACT

55 11 2151-1233

Facility Contacts

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Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Christian B Silva, BSc

Role: primary

+55 88 999855250

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Maria C O Figueiredo, BSc

Role: primary

+55 61 994508218

Marta N S Medeiros, BSc

Role: primary

+55 65 992564577

Marta N S Medeiros, BSc

Role: primary

+55 65 992564577

Marta N S Medeiros, BSc

Role: primary

+55 65 992564577

Marta N S Medeiros, BSc

Role: primary

+55 65 992564577

Marta N S Medeiros, BSc

Role: primary

+55 65 992564577

Marta N S Medeiros, BSc

Role: primary

+55 65 992564577

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Paula M M G Corrêa, BSc

Role: primary

+55 38 999794395

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Rodolfo A Dellagrana, BSc

Role: primary

+55 42 984040300

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Lucinaldo S Blandtt, BSc

Role: primary

+55 91 992006535

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Nayara C Costa, BSc

Role: primary

+55 84 994444998

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Marcos A A +55 95 991445480, BSc

Role: primary

Marcos A A Lima, BSc

Role: primary

+55 95 991445480

Other Identifiers

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EDUCAVAC trial

Identifier Type: -

Identifier Source: org_study_id

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