Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
NCT ID: NCT06513416
Last Updated: 2025-02-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2023-02-01
2025-12-31
Brief Summary
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This study collects preoperative oropharyngeal and fecal samples, as well as preoperative plasma from patients for microbial sequencing and untargeted metabolomics analysis. The main outcome measurement is PPCs, which include pneumonia, atelectasis, and hypoxemia within 7 days after surgery. Inflammatory cells and cytokines in peripheral blood are secondary outcomes.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
OTHER
Study Groups
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PPCs+ group
Patients who experienced postoperative pulmonary complications belong to the PPC positive group
Elective upper abdominal surgery
The included elderly patients are those who are preparing for elective upper abdominal surgery and the surgery time exceeds 2 hours.
PPCs- group
Patients who experienced no postoperative pulmonary complications belong to the PPC negative group
Elective upper abdominal surgery
The included elderly patients are those who are preparing for elective upper abdominal surgery and the surgery time exceeds 2 hours.
Interventions
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Elective upper abdominal surgery
The included elderly patients are those who are preparing for elective upper abdominal surgery and the surgery time exceeds 2 hours.
Eligibility Criteria
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Inclusion Criteria
2. Surgery: Upper abdominal surgery (expected duration ≥ 2 hours);
3. Anesthesia methods: general anesthesia, tracheal intubation;
4. ASA classification: I-IV levels;
5. Postoperative Pulmonary Complications Risk Score (ARISCAT): Medium to High Risk
6. Patients or their families are able to understand the research protocol and are willing to participate in this study, providing written informed consent
Exclusion Criteria
2. This is the second surgery within the past month;
3. Preoperative presence of pulmonary infection or other serious pulmonary complications
4. Patients who have used antibiotics, probiotics, and acid suppressants within one month before surgery
65 Years
ALL
No
Sponsors
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Peking Union Medical College Hospital
OTHER
Responsible Party
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Huang YuGuang
Chief physician
Locations
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Department of Anesthesiology, Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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K5484
Identifier Type: -
Identifier Source: org_study_id
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