Complement C5 mAb in the Treatment of Anti-GBM Disease

NCT ID: NCT06513338

Last Updated: 2025-12-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-03-01
• Study Completion Date: 2025-11-03

Brief Summary

Anti-GBM disease is the most severe form of glomerulonephritis. Despite of the standard treatment including plasmapheresis and immunosuppressant, 70% of the patients still go into end-stage kidney disease. Complement has been shown to participate in the pathogenesis of anti-GBM disease. This study aims to the investigate the therapeutic effects and safety of C5 monoclonal antibody in the treatment of anti-GBM disease.

Detailed Description

Anti-glomerular basement membrane (anti-GBM) disease is the most severe form of autoimmune glomerulonephritis, characterized by the production of autoantibodies targeting the components of basement membrane within the kidney and/or the lung.Patients with anti-GBM disease typically present rapidly progressive glomerulonephritis, and often accompanied by lung hemorrhage. The hallmark of the disease is the linear deposition of IgG along the GBM on kidney biopsy. Complement activation is a pivotal step for kidney injuries during the development of human anti-GBM disease. Our previous study showed that the The levels of plasma SC5b-9 and urinary C5a were positively correlated with the serum creatinine at presentation and the percentage of crescents in glomeruli. Eculizumab is a recombinant humanized monoclonal antibody that specifically binds to a C5 terminal complement and inhibits the cleavage of C5 to C5a and C5b through complement activation. There are a few case reports showing therapeutic effects in anti-GBM disease. This trial will aim to evaluate the efficacy and safety of Eculizumab plus standard treatment in anti-GBM disease.

Conditions

Autoimmune Diseases

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

eculizumab

C5 monoclonal treatment plus standard treatment

Group Type: EXPERIMENTAL

Eculizumab

Intervention Type: DRUG

eculizumab 900mg iv. per week for 4 weeks, then 1200mg every two weeks for 8 weeks

Interventions

Eculizumab

eculizumab 900mg iv. per week for 4 weeks, then 1200mg every two weeks for 8 weeks

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Positive circulating anti-GBM antibody, with proteinuria or hematuria or any clinical signs of kidney injuries.

2. And or kidney biopsy showed typical IgG linear deposition along the GBM

3. At least 18 years old

Exclusion Criteria

1. Allergic to eculizumab, mouse protein or the investigational drug and any of its excipients;

2. Uncontrolled meningococcal infection,or those who have not received meningitis prophylactic antibiotic treatment or meningitis vaccination;

3. Diagnosis of anti-GBM disease for more than 12 weeks before signing the informed consent form;

4. Pregnant or lactating

5. Received investigational drug within 30 days or 4 half-lives (whichever is longer) prior to screening;

6. Other serious poorly controlled comorbid diseases that affect the compliance of the trial protocol or the interpretation of results within 3 months prior to screening, including cardiovascular and cerebrovascular diseases, lung disease, etc.;

7. Presence of any medical history or disease that, in the opinion of the investigator, may expose the patient's participation in the study to an unacceptable risk;

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Peking University First Hospital

OTHER

Sponsor Role: lead

Responsible Party

Zhao CUI

Dr.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Zhao Cui

Role: PRINCIPAL_INVESTIGATOR

PKUFH

Locations

Peking University First Hospital

Beijing, , China

Countries

China

Other Identifiers

C5mAb in anti-GBM disease

Identifier Type: -

Identifier Source: org_study_id