CPK Levels After LC and Association With Analgesic Modalities

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-08-05

Study Completion Date

2025-03-30

Brief Summary

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Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

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Detailed Description

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During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.

Conditions

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Myotoxicity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Interfascial plane blocks

Patients who are preferred to apply interfascial plane blocks as part of multimodal analgesia in the postoperative analgesia plan will be evaluated in this group.

İnterfascial plane block

Intervention Type OTHER

Interfascial plane blocks will be added to the routine analgesia plan as part of multimodal analgesia.

Standart analgesia plan

Intervention Type OTHER

This is the routine analgesia plan applied in our clinic.

Control

Multimodal analgesia plans that does not include interfascial plane blocks

Standart analgesia plan

Intervention Type OTHER

This is the routine analgesia plan applied in our clinic.

Interventions

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İnterfascial plane block

Interfascial plane blocks will be added to the routine analgesia plan as part of multimodal analgesia.

Intervention Type OTHER

Standart analgesia plan

This is the routine analgesia plan applied in our clinic.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* ASA 1-3
* Laparoscopic cholecystectomy
* under General Anesthesia

Exclusion Criteria

* Morbidly obesity or cachexia
* local anesthetic allergies
* myopathies
* coagulopathies
* Obstructive sleep apne syndrome
* hearth diseases
* liver diseases
* kidney diseases
* thyroid-parathyriod dieseas
* hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
* pregnancy

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No