Predicting Response to Chemotherapy in Colorectal Cancer Via Multi-dimensional Analyses of the Tumor Associated Neutrophils

NCT ID: NCT06495827

Last Updated: 2024-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

653 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-07-31

Study Completion Date

2023-08-31

Brief Summary

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A single biomarker is not adequate to identify patients with colorectal cancer (CRC) who have the potential to benefit from adjuvant therapy, presumably owing to the complexity of tumor-infiltrating immune cells (TIICs). The density and spatial organization of TIICs has not been definitely established to explore their predictive value. This study aimed to investigate the prognostic significance of TIICs and its biological predictive value in CRC.

Detailed Description

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Conditions

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Tumor Associated Neutrophils

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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response cohort

CRC patients with response status after chemotherapy

No different intenvention

Intervention Type OTHER

No different intenvention

resistance cohort

CRC patients with resistance status after chemotherapy

No different intenvention

Intervention Type OTHER

No different intenvention

Interventions

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No different intenvention

No different intenvention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Voluntarily sign a written ICF.
2. The Eastern Cancer Collaborative Organization (ECOG) has a physical fitness score of 0 or 1.
3. The expected survival period is ≥ 3 months.

5\. Subjects diagnosed with metastatic colorectal adenocarcinoma by histology or cytology.

6\. Colorectal cancer patients who have not received systematic anti-tumor therapy in the past.

Exclusion Criteria

1. Subjects suffered from other malignant tumors within 3 years before enrollment, except for cured local tumors (such as basal cell skin cancer, squamous cell skin cancer, superficial bladder cancer, cervical carcinoma in situ, etc.).
2. Simultaneously enroll in another clinical study, unless it is an observational, non-interference clinical study or a follow-up period of an intervention study.
3. Received systematic anti-tumor therapy (chemotherapy) within 3 weeks prior to the first administration
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Xu jianmin

Head of colorectal surgery department, Principal Investigator, Clinical Professor, Zhongshan Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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TANs for CT response in CRC

Identifier Type: -

Identifier Source: org_study_id

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