Distinct Metastatic Phenotypes Between Early-onset and Late-onset Colorectal Cancer

NCT ID: NCT06040021

Last Updated: 2023-09-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 15244 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-01-01
• Study Completion Date: 2023-06-30

Brief Summary

The clinical and pathological features of early-onset colorectal cancer (EOCRC) differ from those of late-onset colorectal cancer (LOCRC). Our research aims to thoroughly elucidate the distinctions between them by analyzing clinical prognosis, metastatic patterns, gene expression, and genomic mutation profiles. Our deliberation will uncover latent strategies for personalized therapeutic of both EOCRC and LOCRC.

Conditions

Early-onset Colorectal Cancer; Late-onset Colorectal Cancer

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

EOCRC

Patients aged\<50 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center.

standardized treatment

Intervention Type: OTHER

Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.

IOCRC

Patients aged between 50 to 70 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center.

standardized treatment

Intervention Type: OTHER

Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.

LOCRC

Patients aged between≥70 with colorectal cancer between 2008 and 2018 in Fudan university Shanghai cancer center.

standardized treatment

Intervention Type: OTHER

Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.

Interventions

standardized treatment

Patients enrolled in these 2 cohorts all received standardized treatment of colorectal cancer.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• The initial diagnosis of colonoscopy and pathology belongs to colorectal cancer;
• Patients should sign an informed consent form after fully understanding the purpose, procedures and potential risks of the study, indicating their voluntary participation in the research.

Exclusion Criteria

• Patients with obvious local or systemic severe infection;
• Acute abdomen: intestinal obstruction, peritonitis, intestinal perforation;
• Have a systemic underlying disease that has not been controlled, or is unstable;
• Patients with poor physical fitness or serious other organic diseases who cannot tolerate anesthesia and surgery;
• Women during pregnancy, perinatal and lactation;
• Patients with severe mental disorders (such as schizophrenia, bipolar disorder, etc.) or patients who are mentally incapable or unable to understand the requirements for participation in the study.

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 95 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fudan University

OTHER

Sponsor Role: lead

Responsible Party

LI XIN-XIANG

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

FDU-EOCRC

Identifier Type: -

Identifier Source: org_study_id