Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer

NCT ID: NCT05414461

Last Updated: 2022-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

97 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-10

Study Completion Date

2022-04-30

Brief Summary

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Immunotherapy improved efficacy and survival in selective patients with metastatic colorectal cancer (mCRC), however, limited data revealed the landscape of immunotherapy efficacy. What's more, potential markers have not been comprehensively evaluated to identify responding patients to further improve efficacy.The investigators conducted a single-arm study to investigate the efficacy of combination immunotherapy in patients with mCRC, and the combined regimen is determined by the physician in charge.

Detailed Description

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Conditions

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Colorectal Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Combination treatment

PD-1 inhibitor-based combination treatment

Group Type EXPERIMENTAL

Combinations

Intervention Type DRUG

PD-1 inhibitor-based combinaiton treatment

Interventions

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Combinations

PD-1 inhibitor-based combinaiton treatment

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patients who had both baseline measurable lesion(s) and at least one post-baseline radiological disease reassessment
* patients with identified genomic status

Exclusion Criteria

* patients who received immune monotherapy
* patients who stopped treatment for any reason without identified response assessment.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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First Affiliated Hospital of Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Feng Ye

Chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Site Status

Countries

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China

Other Identifiers

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CombiImmuno mCRC

Identifier Type: -

Identifier Source: org_study_id

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