Heterogeneity of Tertiary Lymphoid Structures Predicts Distinct Malignancy and Immune Microenvironment in Prostate Cancer: a Retrospective Cohort Study

NCT ID: NCT06484127

Last Updated: 2024-07-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-01

Study Completion Date

2024-05-30

Brief Summary

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The aim of this study was to reveal the predictive value of spatial heterogeneity and maturity difference of tertiary lymphoid structure in pathological sections of prostate cancer patients for clinical features and prognosis. It provides a new idea for the selection of prostate cancer immunotherapy population in the future.

Detailed Description

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Conditions

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Prostate Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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tertiary lymphoid structure positive patients

No interventions assigned to this group

tertiary lymphoid structure negative patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1.patients diagnosed with prostate cancer who underwent radical prostatectomy or prostate puncture

Exclusion Criteria

1\. incomplete medical records, inadequate follow-up information, and confirmed non-prostatic acinar adenocarcinoma.
Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Wang Zhongyuan

Study Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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050432-4-2307E

Identifier Type: -

Identifier Source: org_study_id

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