Tumor Associated Macrophage in Advanced Non-small Cell Lung Cancer

NCT ID: NCT01551251

Last Updated: 2015-07-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

107 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-01-31

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this study is to investigate the effects of tumor associated macrophage (TAM) in advanced non-small cell lung cancer (NSCLC) patients on the treatment response and outcome of these subjects. Pathologic specimens from tissue bank will be stained by immunostaining methods with CD68 antibody. The clinical treatment response and outcomes will be analyzed between high or low TAM.

Detailed Description

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Conditions

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Advanced Nonsmall Cell Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Advanced NSCLC with high TAM

All patients with advanced non-small cell lung cancer who had been treated at the Linkou Branch of Chang Gung Memorial Hospital were included. Tumor specimens with high TAM were included as one cohort group.

No interventions assigned to this group

Advanced NSCLC with low TAM

All patients with advanced non-small cell lung cancer who had been treated at the Linkou Branch of Chang Gung Memorial Hospital were included. Tumor specimens with low TAM were included as one cohort group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* advanced NSCLC,
* more than 20 years old,
* measurable tumor,
* response and outcome recorded after the first line treatment.

Exclusion Criteria

* Early stage NSCLC,
* less than 20 years,
* pregnancy,
* unmeasurable NSCLC.
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Chung Fu-Tsai

Chang Gung Memorial Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Fu-Tsai Chung, M.D.

Role: PRINCIPAL_INVESTIGATOR

Chang Gung Memorial Hospital

Locations

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Chang Gung Memorial Hospital

Taipei, Taipei, Taiwan

Site Status

Sant Paul Hospital

Taoyuan District, , Taiwan

Site Status

Countries

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Taiwan

References

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Chen JJ, Lin YC, Yao PL, Yuan A, Chen HY, Shun CT, Tsai MF, Chen CH, Yang PC. Tumor-associated macrophages: the double-edged sword in cancer progression. J Clin Oncol. 2005 Feb 10;23(5):953-64. doi: 10.1200/JCO.2005.12.172. Epub 2004 Dec 14.

Reference Type BACKGROUND
PMID: 15598976 (View on PubMed)

Other Identifiers

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100-0522B

Identifier Type: -

Identifier Source: org_study_id

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