Role of Left Stellate Ganglion Block in Offering Myocardial Protection in On-pump Mitral Valve Replacement? A Histopathological and Clinical Assessment

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-07-15

Study Completion Date

2025-02-20

Brief Summary

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Can pre-operative left stellate ganglion block offer myocardial protection in on-pump mitral valve replacement? A histopathological and clinical assessment.

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Detailed Description

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Conditions

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Open Mitral Cardiac Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Control group

Sonar guided stellate ganglion injection of 8 ml of sterile saline 0.9% using high frequency probe as a placebo. Stellate ganglion is identified at the level of C6 just under the pulsation of the ipsilateral carotid artery

Group Type PLACEBO_COMPARATOR

sonar guided stellate ganglion injection

Intervention Type PROCEDURE

using high frequency probe, sonar guided stellate ganglion block with 8 ml saline 0.9%

Stellate ganglion

Sonar guided stellate ganglion injection of 8ml bupivacaine 0.25% using high frequency probe. . Stellate ganglion is identified at the level of C6 just under the pulsation of the ipsilateral carotid artery

Group Type ACTIVE_COMPARATOR

sonar guided stellate ganglion block

Intervention Type PROCEDURE

using high frequency probe, sonar guided stellate ganglion block with 8 ml bupivacaine 0.25%

Interventions

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sonar guided stellate ganglion injection

using high frequency probe, sonar guided stellate ganglion block with 8 ml saline 0.9%

Intervention Type PROCEDURE

sonar guided stellate ganglion block

using high frequency probe, sonar guided stellate ganglion block with 8 ml bupivacaine 0.25%

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adult population of both sex, between 25-50 years, will undergo elective on pump mitral valve replacement

Exclusion Criteria

* -Combined valve replacement ( mitral and aortic or mitral and tricuspid valves replacement).
* Emergency valve replacement ( stuck valve, infective endocarditis).
* Pre-operative cardiomyopathy (Ejection fraction less than 45%).
* Recent myocardial infarction ( within 6 months)
* Redo mitral valve replacement.
* Pre-operative pacing, or cardioverter, any form arrhythmia ( tachy or brady).
* Previous history of carotid endarterectomy or presence of carotid stent.
* On thrombolytic therapy.
* Severe chronic obstructive airway disease,
* Patient refusal

Minimum Eligible Age

25 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No