Muscle-tendon Interaction in the Spastic Sural Triceps During Gait
NCT ID: NCT06474117
Last Updated: 2024-11-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
80 participants
OBSERVATIONAL
2024-11-15
2026-11-15
Brief Summary
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Detailed Description
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Study Description: Strokes often lead to spastic paresis, degrading patients' walking performance. Instrumented gait analysis allows for the evaluation of these performances to propose adapted therapeutic strategies. This project will compare muscle and tendon behavior during walking between healthy individuals and post-stroke patients.
Methodology:
* Participants: Adult post-stroke patients or incomplete SCI patients with voluntary motor function on the triceps surae and walking capacity. Control group composed of healthy adults.
* Procedures:
* Measure the force/length profile of the GM on an isokinetic dynamometer with simultaneous ultrasound.
* Conduct gait analysis coupled with ultrasound to measure the lengths of the AT and GM.
* Compare muscle and tendon length data during the stance phase of the gait cycle between the two groups.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Post-Stroke Patients
Patients will undergo gait analysis coupled with ultrasound to measure the lengths of the Achilles tendon and gastrocnemius medialis muscle. They will also have their force/length profile of the GM measured on an isokinetic dynamometer with simultaneous ultrasound
Gait analysis coupled with ultrasound
Measure the lengths of the Achilles tendon and gastrocnemius medialis muscle
Isokinetic dynamometer with simultaneous ultrasound
Measure the force/length profile of the gastrocnemius medialis muscle
Post-Spinal Cord Injury Patients
Similar to the post-stroke group, these patients will undergo gait analysis coupled with ultrasound to measure the lengths of the Achilles tendon and gastrocnemius medialis muscle. The force/length profile of the GM will also be measured on an isokinetic dynamometer with simultaneous ultrasound.
Gait analysis coupled with ultrasound
Measure the lengths of the Achilles tendon and gastrocnemius medialis muscle
Isokinetic dynamometer with simultaneous ultrasound
Measure the force/length profile of the gastrocnemius medialis muscle
Healthy controls
The healthy control group will undergo the same gait analysis and ultrasound measurements as the patient groups. Their force/length profile of the GM will also be measured on an isokinetic dynamometer with simultaneous ultrasound for comparison with the post-stroke and post-spinal cord injury groups.
Gait analysis coupled with ultrasound
Measure the lengths of the Achilles tendon and gastrocnemius medialis muscle
Isokinetic dynamometer with simultaneous ultrasound
Measure the force/length profile of the gastrocnemius medialis muscle
Interventions
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Gait analysis coupled with ultrasound
Measure the lengths of the Achilles tendon and gastrocnemius medialis muscle
Isokinetic dynamometer with simultaneous ultrasound
Measure the force/length profile of the gastrocnemius medialis muscle
Eligibility Criteria
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Inclusion Criteria
* Adult male or female
* Patient who had a stroke more than 7 days ago
* Patient hospitalized (in conventional hospitalization or day hospital) in the university neurological rehabilitation department of CHU de Nantes
* Patient with voluntary motor function graded between 2 and 4 on the MRC (Medical Research Council) scale at the GM level
* Patient classified between 3 and 8 on the New Functional Ambulation Classification
Post-Spinal Cord Injury Population:
* Adult male or female
* Patient with an incomplete spinal cord injury classified as ASIA AIS C or D from level C2 to L5
* Patient hospitalized (in conventional hospitalization or day hospital) in the neurological rehabilitation department of CHU de Nantes
* Patient with voluntary motor function graded between 2 and 4 on the MRC (Medical Research Council) scale at the GM level
* Patient classified between 3 and 8 on the New Functional Ambulation Classification
Healthy Population:
• Adult male or female without any neurological disorders
Exclusion Criteria
* Minor patient
* History of calf surgery, surgery to reduce triceps surae spasticity, or intramuscular injection (e.g., botulinum toxin) in the plantar flexors within the last 6 months
* Patient with a progressive condition contraindicating physical exertion (e.g., syrinx, cardiovascular instability)
* Peripheral pathology of the considered lower limb
Healthy Population:
* History of calf surgery
* History of muscle injury, fracture, or sprain of the lower limb within the last 3 months
* History of neurological disorders
18 Years
ALL
Yes
Sponsors
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Laboratoire Motricité, Interactions, Performance (MIP)
UNKNOWN
Société Française de Physiothérapie (SFP).
UNKNOWN
Nantes University Hospital
OTHER
Responsible Party
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Locations
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CHU de Nantes
Nantes, Loire Atlantique, France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024-A01157-40
Identifier Type: OTHER
Identifier Source: secondary_id
RC24_0274
Identifier Type: -
Identifier Source: org_study_id
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