Mechanisms for Atrial Fibrillation in Obstructive Sleep Apnea
NCT ID: NCT06465134
Last Updated: 2024-06-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
300 participants
OBSERVATIONAL
2023-11-01
2026-05-31
Brief Summary
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In this project, teh investigators investigate the occurrence of OSA in AF patients. Furthermore, underlying mechanisms for the development and recurrence of AF after intervention in OSA patients are investigated.
300 patients scheduled for AF ablation or cardioversion are invited and examined with sleep registration, 24h blood pressure, aortic stiffness measurement, test of autonomic function, echocardiography, ECG and labs. The patients are followed at months 3, 6 and 12 with 7 days ECG for recurrence. The aim is to give insights into the need for screening for OSA in patients with AF. The study also aim at enabling preventive treatment through better understanding of underlying treatable mechanisms. The results are believed to lead to fewer new AFs, as well as fewer AF recurrences in patients with OSA.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Group 1
Patients scheduled for AF ablation or cardioversion
No intervention
There is no intervention
Interventions
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No intervention
There is no intervention
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* previous cardiac surgery including AF ablation
* severe valvular heart disease
* diagnosed structural heart disease
* systolic function in sinus rhythm \<50%.
* severe hypertensive heart disease or known hypertrophic heart disease (amyloidosis, hereditary hypertrophic heart disease)
* invalidating chronic diseases imaging material on echocardiography not of sufficient quality.
18 Years
ALL
No
Sponsors
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Istituto Auxologico Italiano
OTHER
University of Trieste
OTHER
Danderyd Hospital
OTHER
Responsible Party
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Principal Investigators
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Kristina Lundwall, MD PhD
Role: PRINCIPAL_INVESTIGATOR
KAROLINSKA INSTITUTE, DANDERYD HOSPITAL
Gianfranco Parati, Professor
Role: PRINCIPAL_INVESTIGATOR
Istituto Auxologico Italiano
Locations
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San Luca Hospital
Milan, , Italy
Cattinara Hospital
Trieste, , Italy
Danderyd Hospital
Stockholm, , Sweden
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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KAROLINSKA INSTITUTE, DANDERYD
Identifier Type: -
Identifier Source: org_study_id
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