Influence of TyG Index and TG/HDL-C Ratio on Fetal Macrosomia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

302 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2024-08-25

Brief Summary

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Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus.

The triglyceride level and other lipids increase slightly during pregnancy. This increase has a positive effect on the development of the fetus. However, an excessive increase in lipid levels can cause some metabolic disorders such as gestational diabetes and increase feto-maternal morbidity/mortality.

While some existing studies have shown that elevated triglyceride levels can cause fetal macrosomia, others have found no correlation between these two variables. The ratio of triglycerides to HDL is a widely used marker for lipid disorders. In addition, the triglyceride-glucose index is also an index used to detect insulin resistance.

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Detailed Description

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In this study, the investigators aimed to investigate whether the ratio of triglycerides to high-density lipoprotein cholesterol and the triglyceride glucose index are associated with fetal macrosomia in low-risk nulliparous pregnant women.

Conditions

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Fetal Macrosomatia Lipid Metabolism Disorders Hyperlipidemias

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Study group

women with macrosomic newborns

TyG index

Intervention Type OTHER

association between TyG index and triglyceride to high-density lipoprotein cholesterol ratio with fetal macrosomia

Control group

women with non-macrosomic newborns

TyG index

Intervention Type OTHER

association between TyG index and triglyceride to high-density lipoprotein cholesterol ratio with fetal macrosomia

Interventions

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TyG index

association between TyG index and triglyceride to high-density lipoprotein cholesterol ratio with fetal macrosomia

Intervention Type OTHER

Other Intervention Names

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Triglyceride to high-density lipoprotein cholesterol ratio

Eligibility Criteria

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Inclusion Criteria

* Screening for fetal macrosomia was based on the term defined according to the standards of the American College of Obstetricians and Gynecologists (ACOG).
* Low-risk nulliparous singleton pregnant women.
* Age between 18 and 40 years old

Exclusion Criteria

* Post-term pregnancies
* Hospitalized for preterm labor or preterm premature rupture of membranes.
* Gestational diabetes mellitus, diabetes mellitus type I - type II.
* Pregnant women with fetal growth restriction, hypertensive pregnancy disorders, familial hypercholesterolemia and hyperlipidemia.
* Multiparous pregnant women
* Multiple pregnancies
* Pregnant women with chronic diseases.
* Pregnant women with impaired liver function;
* Pregnant women with body mass index \<25 and \>40 kg/m2.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes