Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

443 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-07-29

Study Completion Date

2025-01-07

Brief Summary

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This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.

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Detailed Description

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An important aim of tobacco control is to reduce demand for the most harmful products. Therefore, a priori knowledge of substitutability across novel and widely used tobacco products may forecast the impact of policies on product switching. This study will use a novel method, the Experimental Tobacco Marketplace (ETM), to characterize the relative substitutability and appeal (abuse liability) of tobacco products (e.g., conventional cigarettes, nicotine vaping products \[NVP\], heated tobacco products \[HTP\], and nicotine pouch products \[NPP\]), and how the appeal is modulated by relative price, user type, and regulatory environment. Exclusive cigarette smokers and dual cigarette/NVP users, stratified by age, will complete multiple scenarios in the ETM.

Conditions

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Cigarette Smoking Nicotine Vaping

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Participants will complete seven Experimental Tobacco Marketplace conditions. Conventional cigarette price will be parametrically increased, and the purchasing of alternative products measured. Alternative products (i.e. nicotine vaping products, heated tobacco products and nicotine pouches) will be available at different prices in separate conditions (i.e., ½ market price and market price).

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exclusive cigarette smokers

Exclusive cigarette smokers will be recruited and will be exposed to all of the conditions described in the intervention section.

Group Type EXPERIMENTAL

All nicotine/ tobacco products at market price

Intervention Type OTHER

Nicotine/tobacco products available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.

Nicotine vaping products at 1/2 market price

Intervention Type OTHER

Availability of nicotine vaping products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Heated tobacco products at 1/2 market price.

Intervention Type OTHER

Availability of heated tobacco products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Nicotine pouch products at 1/2 market price.

Intervention Type OTHER

Availability of heated tobacco products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Dual cigarette/ nicotine vaping product users

Dual cigarette and nicotine vaping product users will be recruited and will be exposed to all of the conditions described in the intervention section.

Group Type EXPERIMENTAL

All nicotine/ tobacco products at market price

Intervention Type OTHER

Nicotine/tobacco products available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.

Nicotine vaping products at 1/2 market price

Intervention Type OTHER

Availability of nicotine vaping products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Heated tobacco products at 1/2 market price.

Intervention Type OTHER

Availability of heated tobacco products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Nicotine pouch products at 1/2 market price.

Intervention Type OTHER

Availability of heated tobacco products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Interventions

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All nicotine/ tobacco products at market price

Nicotine/tobacco products available in the Experimental Tobacco Marketplace at market price. Note that all participants will complete all the specified conditions.

Intervention Type OTHER

Nicotine vaping products at 1/2 market price

Availability of nicotine vaping products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Intervention Type OTHER

Heated tobacco products at 1/2 market price.

Availability of heated tobacco products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Intervention Type OTHER

Nicotine pouch products at 1/2 market price.

Availability of heated tobacco products in the Experimental Tobacco Marketplace at 1/2 market price. Other nicotine/tobacco products at market price. Note that all participants will complete all the specified conditions.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* From CA, US, or EN
* At least 21 years old
* Smoking daily
* Smoking mostly or about equal amounts of factory-made cigarettes
* Does not currently vape (for exclusive smokers only)
* Vapes Daily (for dual users only)

Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No