Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients
NCT ID: NCT06451016
Last Updated: 2024-06-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
48 participants
INTERVENTIONAL
2021-01-01
2024-01-15
Brief Summary
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A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD).
Methodology:
A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Vitamin D group
Vitamin D supplements
70 mcg/day (equal to 2800 IU) of cholecalciferol
Control Group
Placebo
Matching Placebo
Interventions
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Vitamin D supplements
70 mcg/day (equal to 2800 IU) of cholecalciferol
Placebo
Matching Placebo
Eligibility Criteria
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Inclusion Criteria
* either starting or about to start anti-thyroid medication (ATD)
Exclusion Criteria
* hypercalcemia
* poor renal function (eGFR \< 45 ml/min)
* the presence of malignant disease
18 Years
40 Years
ALL
No
Sponsors
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Frontier Medical and Dental College, Abbotabad
OTHER
Responsible Party
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Dr Saif ur Rehman
Professor
Locations
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Frontier Medical and Dental College
Abbottābād, KPK, Pakistan
Frontier Dental
Abbottābād, Sindh, Pakistan
Countries
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Other Identifiers
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3389
Identifier Type: -
Identifier Source: org_study_id
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