Novel Imaging Biomarkers for Mechanical Complications in Acute Myocardial Infarction

NCT ID: NCT06450912

Last Updated: 2026-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-01

Study Completion Date

2024-06-01

Brief Summary

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Hemorrhagic Myocardial infarctions are at high risk for mechanical complications including cardiac rupture. Prediction of vulnerable myocardial segments is an important step for the stratification of hemorrhagic MI patients. Wall motion index ratio is an important parameter to determine regions of high vulnerability within the 17-segment LV model of hemorrhagic MI.

Detailed Description

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Conditions

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Acute Myocardial Infarction Hemorrhagic Myocardial Infarction Myocardial Stunning Myocardial Hemorrhage Myocardial Reperfusion Injury Myocardial Rupture (Post Infarct)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Index STEMI
* Primary PCI
* Able to complete Cardiac MR - STRAIN Protocol

Exclusion Criteria

* Contraindication to CMR (Contrast Hypersensitivity, Metallic Implants, Abnormal Rhythms, breathing difficulties)
Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rohan Dharmakumar

OTHER

Sponsor Role lead

Responsible Party

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Rohan Dharmakumar

Executive Director, Krannert Cardiovascular Research Center

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Rohan Dharmakumar, PhD

Role: STUDY_DIRECTOR

Indiana University School of Medicine

Keyur P Vora, MD FACC

Role: PRINCIPAL_INVESTIGATOR

Indiana University School of Medicine

Locations

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Krannert Cardiovascular Research Center, Indiana University School of Medicine

Indianapolis, Indiana, United States

Site Status

Countries

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United States

Other Identifiers

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19978e

Identifier Type: -

Identifier Source: org_study_id

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