Application and Clinical Evaluation of Longitudinal Chromatic Aberration Technique in Ophthalmology

NCT ID: NCT06449976

Last Updated: 2024-09-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 21 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-06-01
• Study Completion Date: 2024-08-30

Brief Summary

Our study aims to delve into the effects of shifting the focal point of blue light from video or text displayed on a terminal screen forward on the axial length of the eye, ocular blood flow, visual fatigue, and visual function, that is, its relationship with Video Display Terminal (VDT) syndrome and myopia. By examining the decoding ability of the adult subjects' retina to the clarity of the signal, we will attempt to develop a novel, non-invasive strategy to curb the elongation of the eyeball associated with myopia. Concurrently, we will also focus on the pathophysiological mechanisms underlying VDT syndrome and explore its potential link to the progression of myopia, providing new scientific evidence for the prevention and treatment of this ocular condition. This research is expected to provide robust support for addressing the global issue of myopia and the health challenges posed by VDT syndrome. Ultimately, by integrating global eye health issues with the challenges brought about by VDT syndrome, we will propose intervention and prevention strategies, offering new insights for the advancement of ophthalmology and public health sectors, thereby promoting visual acuity and ocular health for the population.

Conditions

Longitudinal Chromatic Aberration; Blue Light Defocus Manipulation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

Blue Light 2D Defocus Group

The group uses blue channel defocused 2D videos and texts for visual evoked tasks. Participants will undergo a 50-minute visual evoked task using videos and texts processed with the 2D blue channel. The effects of standard video mode on the eye's axial length, refractive labor, and visual function are assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Group Type: EXPERIMENTAL

blue light defocus and blue light filtering

Intervention Type: BEHAVIORAL

Subjects are asked to watch a terminal display device for 50 minutes, featuring texts and videos with different defocusing treatments. Specifically, they will start by watching text for 5 minutes, followed by 40 minutes of video, and then another 5 minutes of text, totaling a visual task duration of 50 minutes. The participants will complete a total of 4 sets of tests in a random order.

Blue Light 1D Defocus with Partial Filtration Group

The group uses videos and texts processed with the blue channel 1D defocus and 30% blue light filtering for visual evoked tasks. Participants will engage in a 50-minute visual evoked task using videos and texts that have been processed with the 1D blue channel and partially filtered for blue light. The impact of the standard video mode on the eye's axial length, refractive labor, and visual function is evaluated, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Group Type: EXPERIMENTAL

blue light defocus and blue light filtering

Intervention Type: BEHAVIORAL

Subjects are asked to watch a terminal display device for 50 minutes, featuring texts and videos with different defocusing treatments. Specifically, they will start by watching text for 5 minutes, followed by 40 minutes of video, and then another 5 minutes of text, totaling a visual task duration of 50 minutes. The participants will complete a total of 4 sets of tests in a random order.

Blue Light 0D Defocus Group

This is the group that performs visual evoked tasks using videos and texts that are not defocused in the blue channel. In this group, the impact of standard video modes on the axial length of the eye, refractive fatigue, and visual function is assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Group Type: EXPERIMENTAL

blue light defocus and blue light filtering

Intervention Type: BEHAVIORAL

Subjects are asked to watch a terminal display device for 50 minutes, featuring texts and videos with different defocusing treatments. Specifically, they will start by watching text for 5 minutes, followed by 40 minutes of video, and then another 5 minutes of text, totaling a visual task duration of 50 minutes. The participants will complete a total of 4 sets of tests in a random order.

Blue Light 1D Defocus Group

Group using blue channel defocused 1D videos and texts for visual evoked tasks. Participants will engage in a 50-minute visual evoked task using videos and texts processed with 1D blue channel. The impact of standard video mode on axial length of the eye, refractive labor, and visual function will be assessed, including but not limited to indicators such as reading efficiency, blinking detection, and retinal fundus blood flow.

Group Type: EXPERIMENTAL

blue light defocus and blue light filtering

Intervention Type: BEHAVIORAL

Subjects are asked to watch a terminal display device for 50 minutes, featuring texts and videos with different defocusing treatments. Specifically, they will start by watching text for 5 minutes, followed by 40 minutes of video, and then another 5 minutes of text, totaling a visual task duration of 50 minutes. The participants will complete a total of 4 sets of tests in a random order.

Interventions

blue light defocus and blue light filtering

Subjects are asked to watch a terminal display device for 50 minutes, featuring texts and videos with different defocusing treatments. Specifically, they will start by watching text for 5 minutes, followed by 40 minutes of video, and then another 5 minutes of text, totaling a visual task duration of 50 minutes. The participants will complete a total of 4 sets of tests in a random order.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. Adult population, regardless of gender

2. Refractive error is less than or equal to -2.5D and both eyes achieve corrected visual acuity of 0.8 or higher.

3. Normal intraocular pressure with no organic pathology.

4. No apparent symptoms of dry eye.

5. Willing to cooperate to complete all the tests.

6. Voluntarily signing the informed consent form.

7. Active corneal infections such as bacterial, fungal, viral, or other acute or chronic anterior segment inflammations.

8. Currently using medications that may lead to dry eye or affect vision and corneal curvature.

9. Other ocular conditions, such as dacryocystitis, eyelid disorders and abnormalities, abnormal intraocular pressure, and glaucoma.

10. Unable to undergo regular eye examinations.

Exclusion Criteria

1. Individuals with strabismus and amblyopia exist.

2. Suffering from congenital eye conditions such as congenital cataracts or congenital retinal diseases.

3. Those who have undergone intraocular surgery (such as cataract removal, intraocular lens implantation, etc.).

4. Individuals with refractive media opacity (such as corneal lesions, lens opacity, etc.).

5. Abnormal intraocular pressure (IOP) (IOP < 10 mmHg or IOP > 21 mmHg, or a bilateral IOP difference of ≥5 mmHg).

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Beijing Tongren Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Beijing Tongren Hospitol, Capital Medical University

Beijing, Beijing Municipality, China

Countries

China

Other Identifiers

BeijingTH-202405

Identifier Type: -

Identifier Source: org_study_id