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Exploring the Impact of Dynamic Defocus Display Schemes on Ocular Health Indicators

NCT ID: NCT07291856

Last Updated: 2025-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-20

Study Completion Date

2025-11-30

Brief Summary

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The present study is designed to explore the effects of dynamic defocus display technology on ocular health parameters using rigorous scientific approaches. It further examines the mechanisms through which this technology alleviates visual fatigue, thereby providing robust clinical evidence to support its practical application and widespread adoption.

Detailed Description

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Research Content Recruit adults who meet the inclusion criteria and have long-term use of VDT (Visual Display Terminal) devices for the trial.

Compare the impact of different dynamic defocus modes on the visual fatigue symptoms of the subjects.

Analyze the mechanisms through which dynamic defocus modes alleviate visual fatigue.

Research Outcome Measures Primary Outcome Measures and Definitions Binocular Visual Function: A series of assessments of visual ability, including accommodative function (amplitude of accommodation, accommodative facility) and vergence function (near point of convergence, AC/A ratio).

Secondary Outcome Measures and Definitions Critical Flicker Fusion Frequency (CFF): To evaluate the degree of eye fatigue, with lower measured values indicating a higher degree of fatigue.

Visual Fatigue Questionnaire Score: To assess the subjective level of visual fatigue experienced by the subjects.

Refraction Results: To monitor changes in refractive status during the trial and evaluate the impact of different dynamic defocus modes on refractive state when using VDT devices at near distance.

Conditions

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Visual Fatigue Myopia

Keywords

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Dynamic Defocus Display Technology Visual Fatigue visual function Repeated Measures Design Longitudinal Chromatic Aberration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This study is designed with a total of five groups, where participants will sequentially and randomly undergo all the intervention procedures.
Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators
In this clinical trial, the masking is applied to the participants and the study staff who conduct the assessments. The participants are single-blinded, meaning they are unaware of the specific dynamic defocus mode they are assigned to during the trial. This is to ensure that their subjective responses, such as those recorded in the visual fatigue questionnaire, are not influenced by their knowledge of the intervention.

The study staff who perform the assessments, including the measurement of critical flicker fusion frequency (CFF), accommodative function, and other ocular health indicators, are also blinded to the group assignments. This helps to prevent any potential bias in the data collection process, ensuring that the measurements are objective and reliable.

The randomization sequence and group assignments are managed by a third-party institution, which maintains the integrity of the blinding. Only after all data have been collected and the initial analysis is complete will the bl

Study Groups

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Control group

This group serves as the baseline comparison. Participants will perform the video-watching task on a conventional display with no intervention, allowing for the assessment of typical visual fatigue and ocular health indicators under standard conditions.

Group Type NO_INTERVENTION

No interventions assigned to this group

Intervention Group A (Low defocus amplitude and high frequency)

Participants will use a display with Dynamic Defocus Mode with low defocus amplitude and high frequency to perform a video browsing task. This group is designed with a specific dynamic defocus adjustment scheme, aimed at investigating the extent to which different dynamic defocus schemes can improve visual fatigue. Participants will be single-blinded to their group assignment. The intervention involves Dynamic Defocus Mode 1 and follows the VDT task protocol as designed in the trial.

Group Type EXPERIMENTAL

Dynamic Defocus Mode

Intervention Type BEHAVIORAL

Participants are required to complete a 50-minute video-watching task using a terminal display device that contains video content processed with different dynamic defocus modes. Specifically, participants will watch the same series of videos in different dynamic defocus modes. Participants will complete a total of 5 sets of video tasks (including the control group) in a random order.

Intervention Group B (low defocus amplitude and low frequency)

Participants will use a display with Dynamic Defocus Mode with low defocus amplitude and low frequency to perform a video browsing task. This group is designed with a specific dynamic defocus adjustment scheme, aimed at investigating the extent to which different dynamic defocus schemes can improve visual fatigue. Participants will be single-blinded to their group assignment. The intervention involves Dynamic Defocus Mode 1 and follows the VDT task protocol as designed in the trial.

Group Type EXPERIMENTAL

Dynamic Defocus Mode

Intervention Type BEHAVIORAL

Participants are required to complete a 50-minute video-watching task using a terminal display device that contains video content processed with different dynamic defocus modes. Specifically, participants will watch the same series of videos in different dynamic defocus modes. Participants will complete a total of 5 sets of video tasks (including the control group) in a random order.

Intervention Group C (high defocus amplitude and high frequency)

Participants will use a display with Dynamic Defocus Mode with high defocus amplitude and high frequency to perform a video browsing task. This group is designed with a specific dynamic defocus adjustment scheme, aimed at investigating the extent to which different dynamic defocus schemes can improve visual fatigue. Participants will be single-blinded to their group assignment. The intervention involves Dynamic Defocus Mode 1 and follows the VDT task protocol as designed in the trial.

Group Type EXPERIMENTAL

Dynamic Defocus Mode

Intervention Type BEHAVIORAL

Participants are required to complete a 50-minute video-watching task using a terminal display device that contains video content processed with different dynamic defocus modes. Specifically, participants will watch the same series of videos in different dynamic defocus modes. Participants will complete a total of 5 sets of video tasks (including the control group) in a random order.

Intervention Group D (high defocus amplitude and low frequency)

Participants will use a display with Dynamic Defocus Mode with high defocus amplitude and low frequency to perform a video browsing task. This group is designed with a specific dynamic defocus adjustment scheme, aimed at investigating the extent to which different dynamic defocus schemes can improve visual fatigue. Participants will be single-blinded to their group assignment. The intervention involves Dynamic Defocus Mode 1 and follows the VDT task protocol as designed in the trial.

Group Type EXPERIMENTAL

Dynamic Defocus Mode

Intervention Type BEHAVIORAL

Participants are required to complete a 50-minute video-watching task using a terminal display device that contains video content processed with different dynamic defocus modes. Specifically, participants will watch the same series of videos in different dynamic defocus modes. Participants will complete a total of 5 sets of video tasks (including the control group) in a random order.

Interventions

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Dynamic Defocus Mode

Participants are required to complete a 50-minute video-watching task using a terminal display device that contains video content processed with different dynamic defocus modes. Specifically, participants will watch the same series of videos in different dynamic defocus modes. Participants will complete a total of 5 sets of video tasks (including the control group) in a random order.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

Adults aged between 20 and 40 years, regardless of gender;

Refractive anisometropia ≤2.5D and corrected visual acuity of 1.0 or above in both eyes;

Habitual long-term use of electronic devices with LED light sources, such as computers and smartphones;

Currently not using any other blue light protection products or having ceased the use of such products for at least 2 weeks;

No known visually significant ophthalmic diseases;

Willing to participate in the trial and having signed the informed consent form.

Exclusion Criteria

Abnormal accommodative function or other visual function abnormalities (e.g., strabismus, amblyopia);

Severe dry eye or history of ocular medication use;

Acute or chronic ocular surface inflammation, keratoconus, history of ocular surgery (e.g., refractive surgery), systemic diseases, or other conditions (e.g., wearing orthokeratology lenses and using atropine);

Photosensitivity, history of epilepsy, etc.;

Individuals unable to cooperate with the examination.
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Beijing Tongren Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Beijing Tongren Hospitol,Capital Medical University

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Other Identifiers

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TREC2025-KY160

Identifier Type: -

Identifier Source: org_study_id