Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
54 participants
INTERVENTIONAL
2023-01-15
2023-06-15
Brief Summary
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Methods: A total of 54volunteer students were included in the present randomized, double-blind, placebo-controlled trial.The participants were divided randomly into two groups; The Control group consisted of 27 participants who consumed placebo ayran, while the 27 participants of the Test group consumed probiotic ayran (containing Lactobacillus acidophilus and Bifidobacterium bifidum) for 42 days twice a day.After 42 days, mechanical plaque control was interrupted for 5 days. The clinical parameters of gingivitis; Plaque index (PI), gingival index (GI), probing bleeding (BOP), probing depth (PPD) were recorded at baseline, day 42 (beginning of experimental gingivitis) and day 47 (the end of experimental gingivitis). At the same time points, gingival crevicular fluid had been collected for analysis of matrix metalloproteinase - 8 (MMP-8).
Detailed Description
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This study evaluates the effects of daily consumption of ayran containing a probiotic combination of Lactobacillus Acidophilus and Bifidobacterium Bifidum on plaque development and gingival status in healthy individuals with experimental gingivitis.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Probiotic ayran drink
The participants in this experimental group will use probiotic containing ayran for 42 days and then will be subjected to 5 days of experimental gingivitis.
probiotic ayran drink
The test group has received probiotic ayran drink for 6 weeks
Placebo ayran drink
The participants in this control group will use control ayran without probiotics for 42 days and then will be subjected to 5 days of experimental gingivitis.
Placebo ayran drink
The control group has received placebo ayran drink for 6 weeks
Interventions
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probiotic ayran drink
The test group has received probiotic ayran drink for 6 weeks
Placebo ayran drink
The control group has received placebo ayran drink for 6 weeks
Eligibility Criteria
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Inclusion Criteria
* Subjects with gingivitis defined as a BOP sites ≥ 10% and PD ≤ 3 mm
* No radiographic bone loss
* Non-smoking participants
Exclusion Criteria
* Undergoing orthodontic treatment,
* Active carious lesions
* Mouth breathing
* History of allergy for milk or fermented milk products.
* Taking medications affecting the gingiva and/or oral mucosa
18 Years
25 Years
ALL
Yes
Sponsors
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Cukurova University
OTHER
Responsible Party
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Cenk Haytac
Professor
Principal Investigators
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Cenk Haytac, phd
Role: PRINCIPAL_INVESTIGATOR
Professor Doctor
Locations
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Cukurova University Faculty of Dentistry
Adana, , Turkey (Türkiye)
Countries
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Other Identifiers
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Cukurova University-1
Identifier Type: -
Identifier Source: org_study_id