A Multicenter Observational Registry to Evaluate Safety and Performance of Vivo ISAR (SECURE Global Registry)

NCT ID: NCT06412250

Last Updated: 2025-09-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-10

Study Completion Date

2027-11-30

Brief Summary

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The objective of this post marketing observational registry is to evaluate clinical outcomes (safety and performance) in an all-comers population with coronary artery disease (CAD) treated with the Polymer Free Sirolimus Eluting Coronary Stent Vivo ISAR and planned for an abbreviated (≤ 3 months) dual antiplatelet therapy (DAPT) regimen.

Detailed Description

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This study is a prospective, observational, multi-country, multi-Centre, single-arm registry designed to evaluate the clinical safety and performance of VIVO ISAR, Polymer Free Sirolimus Eluting Coronary Stent System. The study population is made up of subjects who have undergone PCI using VIVO ISAR and are receiving standard of care short DAPT treatment (≤ 3 months) . Subjects will be screened by site teams and offered the opportunity to participate in the registry after their procedure. Rationale for this study is to evaluate clinical outcomes and collect data of the Polymer Free Sirolimus Eluting Coronary Stent in real world CAD patients with follow-up at 1 month, 3 months and 12 months.

All medications and procedures to be used/ performed in this registry are commonly used/performed for clinical indications as part of standard of care and have well-defined safety profiles.

The study does not influence the choice of device utilized nor does it alter the routine standard of care. After a patient has been treated with the Vivo ISAR, informed consent will be requested and the eligible patient will be registered in the study.

Baseline data will be completed using medical notes. All recruited subjects will then be followed as per routine practice together with telephonic follow-up at 30 days, 3 months and 12 months from the baseline PCI procedure date.

The 30 day, 3 months and 12 month telephonic follow up will consist of a verbally report of the DAPT anticoagulation medications continued, about any lab assessments that might have happened, recording of any adverse events, and any interventional treatment that has occurred since previous contact.

Conditions

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Cardiovascular Diseases

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Ability to provide written informed consent.
2. Treated only with the VIVO ISAR stent system.
3. ≥ 18 years old.
4. Male or non-pregnant female patient.
5. Intended for treatment with ≤ 3 months DAPT after PCI as per standard of care.

Exclusion Criteria

1. Patients having any of the following conditions will not be considered (enrolled) for the study Concurrent participation in an interventional study.
2. Cardiogenic shock/hemodynamic instability around the time of the index procedure.
3. Concurrent medical condition with a life expectancy of less than 12 months.
4. Allergy or contraindication to antiplatelet therapy, cobalt chromium, sirolimus or any known hypersensitivity to the planned anti-platelet drugs.
5. History of cerebrovascular accident in the last 6 months.
6. Pregnant female.
7. PCI performed within the previous 3 months from the date of index procedure
8. Treated with another stent type during the index procedure in addition to the VIVO ISAR stent system
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Iqvia Pty Ltd

INDUSTRY

Sponsor Role collaborator

Translumina Therapeutics Pvt Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Prof Adnan Kastrati

Role: STUDY_CHAIR

German Heart Centre Munich, Germany

Prof Azfar Zaman

Role: PRINCIPAL_INVESTIGATOR

Freeman Hospital, Newcastle, UK

Locations

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Zydus Hospitals

Ahmedabad, , India

Site Status RECRUITING

Fortis Hospital

Bangalore, , India

Site Status RECRUITING

Adesh Hospital

Bathinda, , India

Site Status RECRUITING

PGIMER

Chandigarh, , India

Site Status RECRUITING

National Heart Institute

Delhi, , India

Site Status RECRUITING

Fortis Escorts Heart Institute & Research Centre

Delhi, , India

Site Status RECRUITING

Fortis Escorts Heart Institute & Research Centre

Delhi, , India

Site Status RECRUITING

Medanta-The Medicity

Gurugram, , India

Site Status RECRUITING

Yashoda Hospitals

Hyderabad, , India

Site Status RECRUITING

Shalby Hospital

Jabalpur, , India

Site Status RECRUITING

Fortis Hospital

Kalyān, , India

Site Status RECRUITING

L.P.S Institute of Cardiology

Kanpur, , India

Site Status RECRUITING

Fortis Hospital

Kolkata, , India

Site Status RECRUITING

Dr. Ram Manohar Lohia Hospital (RML)

Lucknow, , India

Site Status RECRUITING

Seva Sadan Hospital

Miraj, , India

Site Status RECRUITING

Fortis

Mohali, , India

Site Status RECRUITING

Yashodha Hospital

Somājigūda, , India

Site Status RECRUITING

ASREM - Regional Hospitals

Campobasso, , Italy

Site Status RECRUITING

Montevergine

Mercogliano AV, , Italy

Site Status RECRUITING

Clinica Mediterranea

Napoli, , Italy

Site Status RECRUITING

University of Padua, Padova

Padua, , Italy

Site Status RECRUITING

Clinica Pierangeli

Pescara, , Italy

Site Status RECRUITING

Santo Spirito Hospital

Pescara, , Italy

Site Status RECRUITING

Tor Vergata University

Roma, , Italy

Site Status RECRUITING

Amsterdam UMC (University Medical Centers)

Amsterdam, , Netherlands

Site Status RECRUITING

Tergooi MC

Hilversum, , Netherlands

Site Status RECRUITING

Viecuri MC

Venlo, , Netherlands

Site Status RECRUITING

Bedford Hospital

Bedford, , United Kingdom

Site Status RECRUITING

Freeman Hospital

Newcastle, , United Kingdom

Site Status RECRUITING

Derriford Hospitalm Plymouth NHS Trust

Plymouth, , United Kingdom

Site Status RECRUITING

Salisbury NHS Foundation Trust

Salisbury, , United Kingdom

Site Status RECRUITING

Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust

Wigan, , United Kingdom

Site Status RECRUITING

Countries

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India Italy Netherlands United Kingdom

Central Contacts

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Diptendu Chatterjee

Role: CONTACT

9339948873

Deepanshi Thakur

Role: CONTACT

9971954733

Facility Contacts

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Nibedita Biswas

Role: primary

Anshul

Role: primary

7052515253

Suhas

Role: primary

7745021465

Bhawani

Role: primary

Other Identifiers

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TL/SECURE/VIVO/2023-01

Identifier Type: -

Identifier Source: org_study_id

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