In-Stent Restenosis Post-Approval Study

NCT ID: NCT02542267

Last Updated: 2023-10-16

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

108 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-30

Study Completion Date

2021-07-31

Brief Summary

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The objective of the ISR 14-04 study is to evaluate post-market safety and effectiveness of GORE® VIABAHN® Endoprosthesis for treatment of In-Stent Restenosis of the Superficial Femoral Artery.

Detailed Description

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Conditions

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Peripheral Artery Disease Vascular Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Gore VIABAHN Endoprosthesis

Gore VIABAHN Endoprosthesis deployed to treat failed non-covered stent(s) in the Superficial Femoral Artery

Group Type OTHER

Gore VIABAHN Endoprosthesis

Intervention Type DEVICE

Interventions

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Gore VIABAHN Endoprosthesis

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient has a previously implanted (\> 30 days) non-covered stent(s) located in the SFA
* Patient has life-style limiting claudication, resting leg pain or minor tissue loss (Rutherford Category 2 - 5)
* Patient demonstrates an Ankle Brachial Index (ABI) \<=0.9. If ABI \>0.9 or not measurable, patient is eligible for study if Toe Brachial Index is \<=0.5
* Patient has \>=50% in-stent restenosis and / or an occlusion in a previously implanted (\>30 days) non-covered stent(s) located in the superficial femoral artery defined as beginning at least 1cm below the origin of the profunda femoris artery and ending at least 1cm above the intercondylar notch.
* Patient has a maximum total lesion length of 270mm, consisting of in-stent and adjacent occlusive disease
* Patient has a reference vessel diameter between 4.0 and 6.5mm
* Patient has at least one patent infrapopliteal runoff vessel (\<50% stenosis) not requiring reintervention

Exclusion Criteria

* Patient has a known allergy to stent graft components (nickel-titanium or expanded-polytetrafluoroethylene)
* Patient has a known intolerance to anticoagulation or antiplatelet therapy
* Patient has known coagulation disorder, including hypercoagulability.
* Patient has major distal amputation (above the transmetatarsal)
* Patient has any previous surgery in the target vessel
* Patient has had previous target vessel in-stent restenosis treated by relining with another stent
* Patient has untreated flow-limiting aortoiliac stenotic disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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W.L.Gore & Associates

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter Soukas, MD

Role: PRINCIPAL_INVESTIGATOR

Miriam Hospital, Providence, RI

Locations

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Mount Sinai Medical Center

Miami, Florida, United States

Site Status

Kaiser Foundation Hospital

Honolulu, Hawaii, United States

Site Status

Rockford CardioVascular Associates

Rockford, Illinois, United States

Site Status

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

Site Status

Cardiovascular Institute of the South

Houma, Louisiana, United States

Site Status

Covenant Medical Center, Inc.

Saginaw, Michigan, United States

Site Status

Munson Medical Center

Traverse City, Michigan, United States

Site Status

Midwest Aortic and Vascular Institute (MAVI)

North Kansas City, Missouri, United States

Site Status

New York University Langone Medical Center

New York, New York, United States

Site Status

New York Presbyterian Hospital/Weill Cornell Medical Center

New York, New York, United States

Site Status

North Carolina Heart and Vascular

Raleigh, North Carolina, United States

Site Status

Sanford Health

Fargo, North Dakota, United States

Site Status

Providence Heart Clinic

Portland, Oregon, United States

Site Status

St. Vincent's Consultants in Cardiovascular Disease

Erie, Pennsylvania, United States

Site Status

The Miriam Hospital

Providence, Rhode Island, United States

Site Status

Greenville Hospital System

Greenville, South Carolina, United States

Site Status

Texas Health Research - Presbyterian Heart and Vascular

Dallas, Texas, United States

Site Status

Texas Health Research - Presbyterian Hospital of Plano

Plano, Texas, United States

Site Status

Swedish Medical Center - Heart and Vascular Research

Seattle, Washington, United States

Site Status

Charleston Area Medical Center

Charleston, West Virginia, United States

Site Status

Klinikum Rosenheim

Rosenheim, , Germany

Site Status

Azienda Ospedaliera Santa Maria Nuova di Reggio Emilia

Reggio Emilia, , Italy

Site Status

Skånes Universitetssjukhus

Malmo, , Sweden

Site Status

Countries

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United States Germany Italy Sweden

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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ISR 14-04

Identifier Type: -

Identifier Source: org_study_id

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