Impact of Topical Pentoxifylline and Tocopherol in Treatment and Prevention of Medically-related Osteonecrosis of the Jaws
NCT ID: NCT06409546
Last Updated: 2024-05-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
48 participants
INTERVENTIONAL
2020-04-02
2024-01-24
Brief Summary
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The aim of the present study is to analyze the impact of topical pentoxifilline and tocopherol in the prevention and treatment of MRNOJ.
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Detailed Description
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48 subjects with MRNOJ, randomly allocated in two groups: placebo group with a 4% hydroxyethyl cellulose adhesive gel and the treatment group with the same gel containing pentoxifilline 5% and tocopherol 75%.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Tocopherol 75% and pentoxifilline 5% gel
Patients treated with a topical gel of tocopherol 75% and pentoxifilline 5%
Tocopherol and pentoxifilline topical gel
Oral gel applied locally on the MRONJ related lesions or post-extraction sockets
Placebo gel
Patients treated with a topical placebo gel control
Placebo
Oral gel applied locally on the MRONJ related lesions or post-extraction sockets
Interventions
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Tocopherol and pentoxifilline topical gel
Oral gel applied locally on the MRONJ related lesions or post-extraction sockets
Placebo
Oral gel applied locally on the MRONJ related lesions or post-extraction sockets
Eligibility Criteria
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Inclusion Criteria
* Need for tooth extraction
Exclusion Criteria
* Oral lesions of hard and soft tissues not related to MRONJ
18 Years
75 Years
ALL
Yes
Sponsors
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University of Catania
OTHER
Responsible Party
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Gaetano Isola
Researcher
Locations
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AOU Policlinico G. Rodolico
Catania, CT, Italy
Countries
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Other Identifiers
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121-31
Identifier Type: -
Identifier Source: org_study_id
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