Supporting Mental Health in Daily Life After the Diagnosis of Multiple Sclerosis

NCT ID: NCT06403631

Last Updated: 2024-07-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

123 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-06

Study Completion Date

2026-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The overall goal of this observational study is to learn about the psychological resources of mindfulness and flow experience available to persons newly diagnosed with multiple sclerosis (MS). The primary study aim will be to analyze the relation of flow and mindfulness with mental health among individuals who received an MS diagnosis within the last year. Secondary aims will be to analyze the daily activities preferentially associated with flow, and to evaluate possible changes in daily flow retrieval. Participants will answer questionnaires measuring flow, mindfulness, positive mental health, anxiety and depression at project start and 6 months later.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The period following Multiple Sclerosis (MS) diagnosis is extremely important to identify and mobilize psychological resources that can support mental health, help cope with challenges, and lead to disease acceptance. Capitalizing on previous studies attesting to the crucial role of attentional skills in disease adjustment, the overall goal of this project is to jointly investigate flow experience and mindfulness as potential resources supporting mental health among newly diagnosed persons. While mindfulness has been widely investigated in relation to MS, flow has been rarely explored. Both constructs are rewarding mental states involving focused attention on the present moment and perceived control over the situation. Yet, they also present relevant differences. Mindfulness is characterized by reflective awareness, while flow by loss of selfconsciousness. Mindfulness can generate initial heightened unpleasant feelings, and its cultivation requires constant practice; instead, flow does not require intensive training and it is reported in association with ordinary daily situations and activities. In light of these differences, it may be suitable to promote flow, or a combination of flow and mindfulness, at the initial stages of MS, as newly diagnosed persons require immediate psychological support and need to find a sense of continuity in life. The primary study aim will be to analyze the relation of flow and mindfulness with mental health among individuals who received an MS diagnosis within the last year.

Secondary aims will be to analyze the daily activities preferentially associated with flow, and to evaluate possible changes in daily flow retrieval. Data will be gathered longitudinally from participants recruited in MS centers across Italy. Participants will fill in online questionnaires measuring flow, mindfulness, positive mental health, anxiety and depression. The questionnaires, including both scaled and open-ended questions, will be proposed at the project start (T1) and 6 months later (T2). Hierarchical regressions and qualitative analyses will be conducted to assess study aims. Both flow and mindfulness are expected to independently contribute to participants' mental health. However, considering its usual occurrence in daily contexts, flow is expected to provide a more relevant contribution than mindfulness, and to play a moderating role in the relation between mindfulness and mental health. The investigators also expect that participants will primarily retrieve flow in productive and leisure activities, and that fewer participants would find flow occasions in their daily life after the diagnosis.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Multiple Sclerosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

observational

Data will be gathered longitudinally from participants newly diagnosed with multiple sclerosis. Participants will fill in online questionnaires measuring flow, mindfulness, positive mental health, anxiety and depression. The questionnaires, including both scaled and open-ended questions, will be proposed at the project start (T1) and 6 months later (T2).

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age 18-50
* clinically-definite MS diagnosed (with McDonald's revised criteria) within the previous 12 months
* steroid treatment for at least 1 month
* written informed consent

Exclusion Criteria

* neurological disorders other than MS
* psychiatric disorders
* severe physical impairment (EDSS=\>8)
* pregnancy
* current or previous attendance in Mindfulness Based Interventions or Acceptance and Commitment Therapy
* severe cognitive impairment in comprehension, attention and execution of inferential-logical operations which could interfere with the ability to fill in questionnaires (equivalent scores 0-1 at Progressive Raven Matrices; score \<11.3 at the visual comprehension of sentences subtest of the Aphasia Neuropsychological Test; score \<37.9 at Symbol Digit Modalities Test; and score \<93.1 at the Brief Test of Intelligence)
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Italian Multiple Sclerosis Foundation

OTHER

Sponsor Role collaborator

Università Vita-Salute San Raffaele

OTHER

Sponsor Role collaborator

Azienda Ospedaliera Sant'Anna

OTHER

Sponsor Role collaborator

San Luigi Gonzaga Hospital

OTHER

Sponsor Role collaborator

University of Florence

OTHER

Sponsor Role collaborator

University of Bari

OTHER

Sponsor Role collaborator

University of Cagliari

OTHER

Sponsor Role collaborator

Azienda Ospedaliera San Camillo Forlanini

OTHER

Sponsor Role collaborator

University of Catania

OTHER

Sponsor Role collaborator

Marta Bassi

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Marta Bassi

Associate Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University of Bari

Bari, , Italy

Site Status RECRUITING

University of Cagliari

Cagliari, , Italy

Site Status RECRUITING

University of Catania

Catania, , Italy

Site Status RECRUITING

Azienda Ospedaliera Sant'Anna

Como, , Italy

Site Status RECRUITING

University of Florence

Florence, , Italy

Site Status RECRUITING

Università Vita-Salute San Raffaele

Milan, , Italy

Site Status RECRUITING

San Luigi Gonzaga Hospital

Orbassano, , Italy

Site Status RECRUITING

Azienda Ospedaliera San Camillo Forlanini

Roma, , Italy

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Italy

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Marta Bassi, PhD

Role: CONTACT

+390250319709

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Pietro Iaffaldano

Role: primary

+390805595368

Eleonora Cocco

Role: primary

+390706093027

Francesco Patti

Role: primary

+390953782642

Monica Grobberio

Role: primary

+390315855896

Maria Pia Amato

Role: primary

+390557947836

Monica Falautano

Role: primary

+390226432870

Alessia Di Sapio

Role: primary

+390119026363

Claudio Gasperini

Role: primary

+390658704349

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2022/R-Multi/020

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

MIndfulness for Students
NCT03669016 UNKNOWN NA