Raman Spectroscopy and Skin Cancer

NCT ID: NCT06384924

Last Updated: 2025-03-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-02-13

Study Completion Date

2027-02-13

Brief Summary

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The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors. The main question it aims to answer is:

-Can Raman Spectroscopy help figure out how far a tumor spreads?

This study will take measurements using laser light from an experimental, handheld probe by lightly touching the skin.

Detailed Description

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Radiation therapy is an alternative to surgery for localized tumors with excellent tumor control and cosmetic outcome. Raman Spectroscopy has potential to be a useful non-invasive, non-destructive, real-time, in-vivo tool for differentiation of cancerous vs. non-cancerous tissues. With this knowledge and future studies, this will ultimately guide skin brachytherapy more accurately and avoid unnecessary radiation to cosmetically and functionally important tissues including eyelid, nose, lips or skin folds.

The purpose of this study is to determine the feasibility of Raman Spectroscopy to identify microscopic infiltration extent of skin cancer beyond grossly visible tumor, using artificial intelligence methods of supervised and un-supervised machine learning algorithms, including pattern recognition, convolutional neural networks, k-means clustering and principal component analysis.

Conditions

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Skin Cancer Basal Cell Carcinoma Squamous Cell Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Raman Spectroscopy

Raman Spectroscopy handheld probe (EmVision, FL, USA)

Intervention Type DEVICE

The probe is approximately the size of a pen or pencil. The handheld probe is connected to the laser source using a cable. The probe is placed in light contact with the skin. The features of the laser light after it bounces off the skin is collected. This measurement can allow us to see tissue characteristics. This is a single session that will take approximately 15 minutes.

Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)

Intervention Type DEVICE

This light source will create the laser light that will pass through the cable and through the handheld probe onto the skin.

Interventions

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Raman Spectroscopy handheld probe (EmVision, FL, USA)

The probe is approximately the size of a pen or pencil. The handheld probe is connected to the laser source using a cable. The probe is placed in light contact with the skin. The features of the laser light after it bounces off the skin is collected. This measurement can allow us to see tissue characteristics. This is a single session that will take approximately 15 minutes.

Intervention Type DEVICE

Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)

This light source will create the laser light that will pass through the cable and through the handheld probe onto the skin.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed skin cancer (either basal cell carcinoma or squamous cell carcinoma)
* Participants must plan to receive brachytherapy treatment for the skin cancer at the study site.
* Ability to provide consent to the study.

Exclusion Criteria

* Patient belongs to a vulnerable population (Minors (under 18 years old), Adults unable to consent, prisoners).
* Lesions on the eyelid or in close proximity to the eye
* Pregnant women, or women of childbearing age who refuse pregnancy testing.
* Patient has pacemaker.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Renee Farrell

OTHER

Sponsor Role lead

Responsible Party

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Renee Farrell

Medical Physicist, Clinical Assistant Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Renee Farrell

Role: PRINCIPAL_INVESTIGATOR

Stony Brook Cancer Center

Locations

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Stony Brook Hospital

Stony Brook, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Renee Farrell

Role: CONTACT

631-216-9087

Facility Contacts

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Renee Cattell, PhD

Role: primary

Other Identifiers

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SBU-RAMAN-SKINCANCER

Identifier Type: -

Identifier Source: org_study_id

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