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In-vivo Optical Coherence Tomography Imaging in Dermatooncology

NCT ID: NCT01680562

Last Updated: 2012-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

37 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2012-12-31

Brief Summary

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In vivo differentiation of benign and malignant skin lesions is a fundamental issue in clinical dermatology. Malignant skin diseases are known to be accompanied by structural alterations. Conventional excisional biopsies and further histopathology are regarded as the reference standard for investigating these pathologies. Biopsies are invasive procedures and additionally may cause side effects. Therefore, research efforts are focused on the development of diagnostic techniques capable of providing in vivo information on the skin's structure. Optical coherence tomography (OCT) is a technical application, which allows the identification of microscopic patterns indicative for benign and malignant skin lesions. OCT is a promising noninvasive imaging technique for the micromorphology of the skin. So far, it's clinical application, as an additional diagnostic tool for malignant skin lesions has been studied in a limited extend. To evaluate the clinical usefulness of OCT, we conducted a prospective pilot study at the Department of Dermatology, Medical University of Vienna. The study is in cooperation with the Center of Biomedical Engineering and Physics at the Medical University of Vienna.

A total of 70 malignant skin lesions was evaluated during this prospective pilot study. Diagnoses based on OCT imaging as an additional diagnostic tool, were compared to those based on the clinical standard pathway at the Department of Dermatology, Medical University of Vienna. For the purpose of this study, the histopathological diagnosis was used as the reference diagnostic standard.

The major aims of this study is the investigation of the ability of ultrahigh resolution OCT to identify fine morphological characteristics associated with basal cell carcinoma, actinic keratosis, superficial squamous cell carcinoma, seborrheic keratosis, melanocytic nevi and melanoma.

* To correlate the morphologic features identified with ultrahigh resolution OCT with routine histopathology
* To investigate the clinical feasibility of ultrahigh resolution and spectroscopic OCT technology
* To assess the effectiveness of ultrahigh resolution and spectroscopic OCT imaging to diagnose various melanocytic and non-melanocytic skin tumors
* To compare the diagnostic capabilities of ultrahigh resolution OCT with standard non-invasive diagnostic procedures such as epiluminescence microscopy

Detailed Description

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Optical coherence tomography (OCT) is a technical application, which allows the identification of microscopic patterns indicative for benign and malignant skin lesions. It is a promising non-invasive imaging technique for the micromorphology of the skin. OCT provides in vivo cross sectional tomographic images of tissue in situ and real-time with micrometer resolution. It works analogously to ultrasound; the reflection of infrared light, instead of acoustical waves, from the skin is measured and the signal strength is imaged as a function of position. Depending on the scattering properties of tissue and some accepted loss in resolution, a penetration depth of up to 2 mm can be achieved. The image data are displayed by assigning color or gray scales to each reflection, according to the measured signal strength. The OCT probe is applied directly after application of ultrasound gel to the skin. Acquisition time for an OCT image is approximately 3 seconds.

Conditions

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Non-melanocytic Skin Tumors Melanocytic Skin Tumors

Keywords

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in-vivo skin imaging non-invasive non-melanoma skin cancer diagnostics

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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skin cancer

Skin cancer patients with scheduled tumor excision and subsequent histopathological analysis of the tumor.

in-vivo skin tumor imaging via optical coherence tomography

Intervention Type OTHER

optical coherence tomography imaging of skin lesion; digital dermoscopy imaging of skin lesion

Interventions

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in-vivo skin tumor imaging via optical coherence tomography

optical coherence tomography imaging of skin lesion; digital dermoscopy imaging of skin lesion

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* seborrhoeic warts
* nevi
* dermatofibroma
* basal cell carcinoma
* actinic keratosis
* squamous cell carcinoma
* Bowen's disease
* Merkel cell carcinoma
* malignant melanoma

Exclusion Criteria

* employers of the Medical University of Vienna
* patients during compulsory military service
* patients with an appointed guardian
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Medical University of Vienna

OTHER

Sponsor Role lead

Responsible Party

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Jessika Weingast, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael Binder, MD

Role: PRINCIPAL_INVESTIGATOR

Medical University of Vienna

Locations

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Department of Dermatology, Medical University of Vienna

Vienna, , Austria

Site Status

Countries

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Austria

Other Identifiers

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201880

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

1126/2009

Identifier Type: -

Identifier Source: org_study_id