Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
180 participants
OBSERVATIONAL
2024-06-22
2027-07-31
Brief Summary
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The aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention (fluid challenge, vasopressor or inotropic drug).
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Detailed Description
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Over the past two decades, great advances have been made in the understanding the pathophysiology of septic shock. Microcirculatory abnormalities have been identified as the main cause of organ hypoperfusion and visceral failure leading to death. In addition, several studies in animals and humans have highlighted a discordance between systemic hemodynamic parameters and alterations of small vessels during shock suggesting that microvascular blood flow and tissue perfusion should be analyzed in patients with acute circulatory failure in association with blood pressure and cardiac output. Capillary refill time (CRT), is an easy-to-use, easy-to learn tool to evaluate peripheral tissue perfusion. CRT is a strong predictive factor of organ failure severity and poor outcome in critically ill patients with sepsis. A recent randomized trial reported promising results regarding the use of CRT to guide resuscitation. However, little is known about the impact of treatment on CRT. The aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention (fluid challenge, vasopressor or inotropic drug).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Fluid challenge
Impact of fluid challenge on peripheral tissue perfusion on sepsis patients
No interventions assigned to this group
Vasopressors
Impact of vasopressors on peripheral tissue perfusion on sepsis patients
No interventions assigned to this group
Inotrope
Impact of dobutamine on peripheral tissue perfusion on patients with septic or cardiogenic shock
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Hemorrhagic shock
* Severe skin lesions
18 Years
ALL
No
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Locations
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Saint -Antoine Hospital_Médecine Intensive Reanimation
Paris, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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APHP231342
Identifier Type: -
Identifier Source: org_study_id
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