Predicting Outcomes of GPOEM Using Gastric Electrical Mapping

NCT ID: NCT06381349

Last Updated: 2025-03-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-07-07

Study Completion Date

2026-06-01

Brief Summary

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Gastric peroral endoscopic myotomy (GPOEM) is a minimally-invasive procedure that involves dividing the pylorus, to enhance gastric emptying in gastroparesis patients. This is a single-arm, multi-centre, prospective observational study to determine the clinical utility of Gastric Alimetry in predicting GPOEM treatment outcomes. The investigators further aim to develop a clinical decision rule to inform patient selection. Gastric Alimetry will be conducted \<1 month prior to GPOEM. All subjects will then be followed up for 12 months.

Detailed Description

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This protocol proposes no change to the clinical management of patients which is left to the discretion of the patients' primary clinical team.

Patients as part of this study will undergo a baseline assessment via Gastric Alimetry, and concurrent symptom, quality of life, and health psychology questions.

GPOEM will be performed as per standard site protocol, with data captured in RDCap.

Patients will be followed up at 1-month, 3-month, 6-months, and 12-months using the myCap (REDCap) app.

Participants and clinicians can opt-in for a repeat Gastric Alimetry test at 6 or 12 months following their GPOEM procedure.

Conditions

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Gastroparesis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Adult patients with gastroparesis

1. Provision of signed and dated informed consent form understand the risks and benefits of the study
2. Aged ≥18 years old
3. Patients must be clinically selected for GPOEM at their respective study site.
4. Patients are undergoing their index GPOEM procedure

Gastric Alimetry test

Intervention Type DIAGNOSTIC_TEST

Gastric Alimetry test will be performed within 30-days prior to G-POEM procedure. It's results will not inform clinical management in this observational study.

Interventions

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Gastric Alimetry test

Gastric Alimetry test will be performed within 30-days prior to G-POEM procedure. It's results will not inform clinical management in this observational study.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Aged 18 years or older
* Indicated for GPOEM

Exclusion Criteria

* Pregnant or breast-feeding
* Inability to perform Gastric Alimetry test: history of severe skin allergies or sensitivity to cosmetics or lotions; chronically damaged or vulnerable epigastric skin (fragile skin, wounds, inflammation); patients unable to remain in a relaxed reclined position for the test duration.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chris Varghese

OTHER

Sponsor Role lead

Responsible Party

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Chris Varghese

Lead Clinical Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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University of Auckland

Auckland, Auckland, New Zealand

Site Status RECRUITING

Countries

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New Zealand

Central Contacts

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Chris Varghese, MBChB

Role: CONTACT

+64 (0) 9 923 9820

Facility Contacts

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Chris Varghese, MBChB

Role: primary

+64 (0) 9 923 9820

Other Identifiers

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GPOEM-GEMS

Identifier Type: -

Identifier Source: org_study_id

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