TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models
NCT ID: NCT06372054
Last Updated: 2024-04-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
200 participants
OBSERVATIONAL
2024-02-05
2027-02-05
Brief Summary
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Detailed Description
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The study aims to collect exposure data, clinical, physiological data through biosensors and molecular parameters (at different time point), to be integrated by an Artificial Intelligence algorithm expressly trained to create reliable risk models.
The final outcome will consist of the identification of significant biomarkers of pathological risk, in order to better understand the etiopathological mechanisms of many human diseases and apply early and personalized countermeasures to maintain and empower workers' health status and performance, avoiding clinical symptom presentation.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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High-performance Italian Air Force Pilots
The primary study cohort is represented by "super-healthy" high-performance Italian Air Force Pilots, aged between 26 and 38 years, in active flight service.
Intervention: not applicable
Biological sample collection
Collection of biological samples (blood, urine, saliva) and clinical data
Italian Air Force ground staff
This cohort of Italian Air Force ground personnel will be used as a control group to compare data from the pilot cohort.
Biological sample collection
Collection of biological samples (blood, urine, saliva) and clinical data
Interventions
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Biological sample collection
Collection of biological samples (blood, urine, saliva) and clinical data
Eligibility Criteria
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Inclusion Criteria
* Age between 26 and 38 years
* Consent to collect biological samples and use the wearable device to monitor exposure parameters
Exclusion Criteria
* no signature on informed consent
26 Years
38 Years
ALL
No
Sponsors
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University of Milan
OTHER
Italian Air Force
UNKNOWN
A-Tono
UNKNOWN
Ministry of Defense, Italy
UNKNOWN
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
OTHER
Responsible Party
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Principal Investigators
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Giovanni Marfia, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Fondazione IRCCs Ca' Granda Ospedale MAggiore Policlinico, Italian Air Force
Emanuele Garzia, MD, PhD
Role: STUDY_CHAIR
Italian Air Force
Marco Locatelli, MD, PhD
Role: STUDY_CHAIR
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Francesco Vestito, PhD
Role: STUDY_CHAIR
Italian Air Force
Locations
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CeMATA - Joint Center for Aerospace Medicine and Advanced Therapy
Milan, , Italy
Countries
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Central Contacts
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Facility Contacts
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References
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Marfia G, Navone SE, Guarnaccia L, Campanella R, Locatelli M, Miozzo M, Perelli P, Della Morte G, Catamo L, Tondo P, Campanella C, Lucertini M, Ciniglio Appiani G, Landolfi A, Garzia E. Space flight and central nervous system: Friends or enemies? Challenges and opportunities for neuroscience and neuro-oncology. J Neurosci Res. 2022 Sep;100(9):1649-1663. doi: 10.1002/jnr.25066. Epub 2022 Jun 9.
Marfia G, Guarnaccia L, Navone SE, Ampollini A, Balsamo M, Benelli F, Gaudino C, Garzia E, Fratocchi C, Di Murro C, Ligarotti GK, Campanella C, Landolfi A, Perelli P, Locatelli M, Ciniglio Appiani G. Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine. Front Physiol. 2023 Mar 14;14:1124991. doi: 10.3389/fphys.2023.1124991. eCollection 2023.
Other Identifiers
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TORNADO
Identifier Type: -
Identifier Source: org_study_id
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