Optic Nerve Sheath Diameter: A Non-Invasive Indicator of Intracranial Pressure in the Intensive Care Unit Monitoring

NCT ID: NCT06367868

Last Updated: 2024-04-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-09

Study Completion Date

2022-12-01

Brief Summary

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Determination of high intracranial pressure (ICP) is necessary for the treatment of patients with raised ICP to improve long-term neurological outcomes. Ultrasonographic optic nerve sheath diameter (ONSD) measurement is a noninvasive, easily performed and cost effective technique for detecting high ICP.

Detailed Description

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ICP measurements via ventricular catheters provide CSF drainage and ICP reduction. The normal ICP value is less than 15 mmHg in adults. In the literature the correlation of ONSD and invasive ICP measurements were determined. The aim of study is to evaluate the correlation of ONSD and direct ICP measurements and to determine cut off ONSD value to detect ICP ≥15 mmHg.

Conditions

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ICP (Intracranial Pressure) Increase Optic Nerve Sheath Diameter Intracranial Hypertension

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Before Drainage

Optic nerve sheath diameter and intracranial pressure will be measured before CSF drainage

Group Type EXPERIMENTAL

After 5 ml CSF Drainage

Intervention Type PROCEDURE

Optic Nerve Sheath Diameter and Intracranial Pressure measurements will be after 5 ml CSF drainage

Interventions

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After 5 ml CSF Drainage

Optic Nerve Sheath Diameter and Intracranial Pressure measurements will be after 5 ml CSF drainage

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18-80 aged patients
* With an external ventricular drainage catheter due to intracranial pathology

Exclusion Criteria

* Under the age of 18
* Orbital tumors
* Graves' disease
* Exophthalmos
* Sarcoidosis
* Optic neuropathy
* Meningitis
* Ocular trauma
* Lung diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Istanbul University - Cerrahpasa

OTHER

Sponsor Role lead

Responsible Party

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Gülşah ORAK

Medical Doctor-Anesthesiology and Reanimation

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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GULSAH ORAK

Role: STUDY_DIRECTOR

Istanbul University - Cerrahpasa

OZLEM KORKMAZ DİLMEN

Role: STUDY_CHAIR

Istanbul University - Cerrahpasa

EREN FATMA AKCİL

Role: STUDY_CHAIR

Istanbul University - Cerrahpasa

Locations

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Istanbul University-Cerrahpasa

Istanbul, Fatıh, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Robba C, Santori G, Czosnyka M, Corradi F, Bragazzi N, Padayachy L, Taccone FS, Citerio G. Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: a systematic review and meta-analysis. Intensive Care Med. 2018 Aug;44(8):1284-1294. doi: 10.1007/s00134-018-5305-7. Epub 2018 Jul 17.

Reference Type BACKGROUND
PMID: 30019201 (View on PubMed)

Muller SJ, Henkes E, Gounis MJ, Felber S, Ganslandt O, Henkes H. Non-Invasive Intracranial Pressure Monitoring. J Clin Med. 2023 Mar 13;12(6):2209. doi: 10.3390/jcm12062209.

Reference Type BACKGROUND
PMID: 36983213 (View on PubMed)

Sharawat IK, Kasinathan A, Bansal A, Sahu JK, Sodhi KS, Dogra MR, Sankhyan N. Evaluation of Optic Nerve Sheath Diameter and Transcranial Doppler As Noninvasive Tools to Detect Raised Intracranial Pressure in Children. Pediatr Crit Care Med. 2020 Nov;21(11):959-965. doi: 10.1097/PCC.0000000000002523.

Reference Type BACKGROUND
PMID: 32852360 (View on PubMed)

Kimberly HH, Shah S, Marill K, Noble V. Correlation of optic nerve sheath diameter with direct measurement of intracranial pressure. Acad Emerg Med. 2008 Feb;15(2):201-4. doi: 10.1111/j.1553-2712.2007.00031.x.

Reference Type BACKGROUND
PMID: 18275454 (View on PubMed)

Other Identifiers

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E-83045809-604.01.02-179951

Identifier Type: -

Identifier Source: org_study_id

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