APA and PAS Training for Gait Initiation in Parkinson's Disease
NCT ID: NCT06363071
Last Updated: 2024-04-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2022-06-13
2025-05-31
Brief Summary
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Detailed Description
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Research indicates that non-motor disorders and cognitive impairments are prevalent in most patients with Parkinson's disease. These include balance issues, postural instability, impaired cognitive functions like working memory and executive functions, and gait instability. Additionally, electrophysiological phenomena in Parkinson's disease patients reveal abnormal central excitatory and inhibitory responses compared to healthy individuals.
This experiment seeks to investigate the link between motor performance and brain excitability in patients with Parkinson's disease. Previous studies suggest that associative electrical stimulation, used to regulate sensorimotor information integration, can enhance brain excitability in both healthy individuals and those with Parkinson's disease. However, the optimal parameters for this stimulation remain uncertain.
Furthermore, balance exercise training can improve motor performance in Parkinson's disease patients. This study aims to determine if various designs of associative electrical stimulation parameters can help these patients achieve optimal brain excitability regulation. The combined approach of this stimulation and balance exercise training aims to maintain and improve the patients' functional performance, thereby enhancing the safety of their daily activities.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Stage 1:Healthy people
To establish PAS baseline and reliability.
Paired associative stimulation
Use TMS combine ES to stimulate TA nerve and M1 cortical
Stage 2:PD people
To establish stage 3 training protocol.
Paired associative stimulation
Use TMS combine ES to stimulate TA nerve and M1 cortical
Stage 3:PD people
Control group.
No interventions assigned to this group
Stage 3: PD APA training group
Weight shift training and APA feedback.
Weight shift training and APA feedback
Use COP trajectory to train weight shift on force plate. To give APA visual feedback for subjects after weight shift training.
Stage 3:PD PAS group
Using PAS to regulate brain plasticity
Paired associative stimulation
Use TMS combine ES to stimulate TA nerve and M1 cortical
Interventions
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Weight shift training and APA feedback
Use COP trajectory to train weight shift on force plate. To give APA visual feedback for subjects after weight shift training.
Paired associative stimulation
Use TMS combine ES to stimulate TA nerve and M1 cortical
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Osteoporosis.
PD subjects:
* Musculoskeletal injuries on legs
* Osteoporosis.
* Any peripheral or central nervous system injury or disease patients.
20 Years
ALL
Yes
Sponsors
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Chang Gung University
OTHER
Responsible Party
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Ya-Ju Chang
Professor
Locations
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Chang Gung University
Taoyuan District, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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202000495A3
Identifier Type: -
Identifier Source: org_study_id
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