Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2024-05-01
2025-07-21
Brief Summary
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There is compelling evidence that intermittent hand and forearm cold-water immersion effectively reduces the rise of core temperature during heat stress in older adults. However, it is still unknown if this is an effective cooling strategy for older adults. Furthermore, our laboratory has shown that folic acid supplementation improves blood flow responses in older adults. This may be beneficial to older adults during heat stress.
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Detailed Description
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Subjects participate in 4 experimental trials, 2 while on folic acid supplementation and 2 while on placebo. The order of treatment (folic acid supplementation or placebo) is randomized. Participants will place their hands and forearms in cold tap water intermittently for one of the two trials for each treatment. The order of the hand and forearm immersion trial is randomized for each treatment. The trials are separated by at least five days. For each experiment, core temperature, heart rate, blood pressure, skin temperature, and sweat rate are measured. Each experimental visit will last 2 hours.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Folic acid supplementation
5 mg/day folic acid for 6-7 weeks
Intermittent cold-water hand and forearm immersion
Participants will be seated at rest in a hot and humid environment. At 2 time points in the experiment, participants will place their hands and forearms in a bucket of cold tap water for 10 minutes.
No intermittent cold-water hand and forearm immersion
Participants will be seated at rest in a hot and humid environment.
Control
Cellulose placebo tablet for 6-7 weeks
Intermittent cold-water hand and forearm immersion
Participants will be seated at rest in a hot and humid environment. At 2 time points in the experiment, participants will place their hands and forearms in a bucket of cold tap water for 10 minutes.
No intermittent cold-water hand and forearm immersion
Participants will be seated at rest in a hot and humid environment.
Interventions
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Intermittent cold-water hand and forearm immersion
Participants will be seated at rest in a hot and humid environment. At 2 time points in the experiment, participants will place their hands and forearms in a bucket of cold tap water for 10 minutes.
No intermittent cold-water hand and forearm immersion
Participants will be seated at rest in a hot and humid environment.
Eligibility Criteria
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Inclusion Criteria
* English proficiency
Exclusion Criteria
* Abnormal resting exercise electrocardiogram (ECG)
* Tobacco use
* High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor Assessment
* Antiepileptic or antiseizure medications
* Methotrexate
65 Years
100 Years
ALL
Yes
Sponsors
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Penn State University
OTHER
Responsible Party
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W. Larry Kenney
Professor of Kinesiology and Physiology
Principal Investigators
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W. Larry Kenney, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
The Pennsylvania State University
Locations
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Noll Laboratory
University Park, Pennsylvania, United States
Countries
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Other Identifiers
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STUDY24458
Identifier Type: -
Identifier Source: org_study_id
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