Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
1 participants
INTERVENTIONAL
2024-01-01
2025-10-01
Brief Summary
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Detailed Description
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Elderly individuals are disproportionately more likely to become ill or die during heat waves. While the elderly have a reduced ability to regulate their body temperature,8-10 hospitalizations and deaths in this population during heat waves are primarily due to cardiovascular and/or respiratory complications, not solely hyperthermia. While previous research has primarily focused on the thermal and cardiovascular consequences of healthy aging, very little research has focused on the physiological responses to heat exposure in older individuals with chronic disease, such as chronic obstructive pulmonary disease (COPD). Notably, epidemiological data suggests that pulmonary complications are a leading cause of heat wave-related hospitalizations in older adults with a diagnosis of COPD, yet nothing is known regarding the physiological mechanisms by which those with COPD are most susceptible to heat waves. To fill this important gap, the investigators will identify the physiological responses that occur in this population, relative to healthy age-matched individuals, during two unique heat wave simulations.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
NONE
Study Groups
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Experimental: Very hot and dry
Subjects will be exposed to 3 hours in a climate chamber set to approximately 47 deg C and 15% relative humidity, which reflects a very hot and dry heat wave condition similar to the 2018 Los Angeles heat wave. Two visits will be required to complete this arm, with one visit including water spray for cooling.
Water Spray
Participants will receive water spraying on their body throughout the climate chamber exposure.
Control
Participants will NOT receive water spraying on their body throughout the climate exposure.
Experimental: Hot and humid
Subjects will be exposed to 3 hours in a climate chamber set to approximately 41 deg C and 40% relative humidity, which reflects hot and humid heat wave similar to the 1995 Chicago heat wave. Two visits will be required to complete this arm, with one visit including water spray for cooling.
Water Spray
Participants will receive water spraying on their body throughout the climate chamber exposure.
Control
Participants will NOT receive water spraying on their body throughout the climate exposure.
Interventions
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Water Spray
Participants will receive water spraying on their body throughout the climate chamber exposure.
Control
Participants will NOT receive water spraying on their body throughout the climate exposure.
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of COPD
Exclusion Criteria
* Other chronic medical conditions requiring regular medical therapy including cancer, diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia etc
* Abnormality detected on routine screening suggestive of provokable ischemia or previously undetected cardiac disease or resting left bundle branch block on screening electrocardiogram
* Current smokers
* Participant with a body mass index ≥31 kg/m2
65 Years
ALL
No
Sponsors
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American Heart Association
OTHER
University of Texas Southwestern Medical Center
OTHER
Responsible Party
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Craig Crandall
Professor of Internal Medicine
Locations
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Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States
Countries
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Other Identifiers
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STU_2019_1759_COPD
Identifier Type: -
Identifier Source: org_study_id
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