Communicating Human Papillomavirus Vaccine With Japanese Parents and Caregivers With Daughters Aged 12-18
NCT ID: NCT06347627
Last Updated: 2024-04-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
1600 participants
INTERVENTIONAL
2023-12-22
2024-12-31
Brief Summary
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Detailed Description
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The sixteen messages will assess four factors: messenger, style, content, and misinformation. Each message will be similar except for one variable in consideration. The messenger component will be whether the message is from an individual or an organization. As individual messengers, the study will set a fictional male or female with common Japanese names who actively communicate about HPV vaccines. As organizational messengers, the study will use the existing accounts of the Ministry of Health, Labour and Welfare or the Japan Cancer Society or a fictional account of an anti-vaccine group. The style component will be whether the message conveys information through storytelling or scientific data. Messages will include personal stories for the storytelling style and statistics for the scientific data style. The content component will be whether the message conveys information about the effectiveness of the HPV vaccine in preventing diseases or the safety of the HPV vaccine. The contents will be built on both factual information and misconceptions about HPV vaccine safety and effectiveness that are often mentioned in the actual social media posts. The misinformation component will be whether the message conveys misinformation or factual information. The study will debrief all respondents exposed to misinformation after the survey.
Lastly, the study will collect data as a post-experiment survey to evaluate how an online message influenced caregivers' trust, confidence, and motivation to vaccinate.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
HEALTH_SERVICES_RESEARCH
TRIPLE
Study Groups
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Group 1 (I x S x S x F)
Participants in Group 1 will view a message in an X (former Twitter) format composed of "Individual x Safety x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 1 (I x S x S x F)
Experimental message: Individual x Safety x Storytelling x Factual
Group 2 (O x S x S x F)
Participants in Group 2 will view a message in an X (former Twitter) format composed of "Organization x Safety x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 2 (O x S x S x F)
Experimental message: Organization x Safety x Storytelling x Factual
Group 3 (I x E x S x F)
Participants in Group 3 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 3 (I x E x S x F)
Experimental message: Individual x Effectiveness x Storytelling x Factual
Group 4 (O x E x S x F)
Participants in Group 4 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Storytelling x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 4 (O x E x S x F)
Experimental message: Organization x Effectiveness x Storytelling x Factual
Group 5 (I x S x S x M)
Participants in Group 5 will view a message in an X (former Twitter) format composed of "Individual x Safety x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 5 (I x S x S x M)
Experimental message: Individual x Safety x Storytelling x Misinformation
Group 6 (O x S x S x M)
Participants in Group 6 will view a message in an X (former Twitter) format composed of "Organization x Safety x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 6 (O x S x S x M)
Experimental message: Organization x Safety x Storytelling x Misinformation
Group 7 (I x E x S x M)
Participants in Group 7 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 7 (I x E x S x M)
Experimental message: Individual x Effectiveness x Storytelling x Misinformation
Group 8 (O x E x S x M)
Participants in Group 8 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Storytelling x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 8 (O x E x S x M)
Experimental message: Organization x Effectiveness x Storytelling x Misinformation
Group 9 (I x S x D x F)
Participants in Group 9 will view a message in an X (former Twitter) format composed of "Individual x Safety x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 9 (I x S x D x F)
Experimental message: Individual x Safety x Scientific data x Factual
Group 10 (O x S x D x F)
Participants in Group 10 will view a message in an X (former Twitter) format composed of "Organization x Safety x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 10 (O x S x D x F)
Experimental message: Organization x Safety x Scientific data x Factual
Group 11 (I x E x D x F)
Participants in Group 11 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 11 (I x E x D x F)
Experimental message: Individual x Effectiveness x Scientific data x Factual
Group 12 (O x E x D x F)
Participants in Group 12 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Scientific data x Factual" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 12 (O x E x D x F)
Experimental message: Organization x Effectiveness x Scientific data x Factual
Group 13 (I x S x D x M)
Participants in Group 13 will view a message in an X (former Twitter) format composed of "Individual x Safety x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 13 (I x S x D x M)
Experimental message: Individual x Safety x Scientific data x Misinformation
Group 14 (O x S x D x M)
Participants in Group 14 will view a message in an X (former Twitter) format composed of "Organization x Safety x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 14 (O x S x D x M)
Experimental message: Organization x Safety x Scientific data x Misinformation
Group 15 (I x E x D x M)
Participants in Group 15 will view a message in an X (former Twitter) format composed of "Individual x Effectiveness x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 15 (I x E x D x M)
Experimental message: Individual x Effectiveness x Scientific data x Misinformation
Group 16 (O x E x D x M)
Participants in Group 16 will view a message in an X (former Twitter) format composed of "Organization x Effectiveness x Scientific data x Misinformation" factors. The message will be available for participants to view while answering five questions that evaluate how it influenced caregivers' trust, confidence, and motivation to vaccinate.
Group 16 (O x E x D x M)
Experimental message: Organization x Effectiveness x Scientific data x Misinformation
Interventions
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Group 1 (I x S x S x F)
Experimental message: Individual x Safety x Storytelling x Factual
Group 2 (O x S x S x F)
Experimental message: Organization x Safety x Storytelling x Factual
Group 3 (I x E x S x F)
Experimental message: Individual x Effectiveness x Storytelling x Factual
Group 4 (O x E x S x F)
Experimental message: Organization x Effectiveness x Storytelling x Factual
Group 5 (I x S x S x M)
Experimental message: Individual x Safety x Storytelling x Misinformation
Group 6 (O x S x S x M)
Experimental message: Organization x Safety x Storytelling x Misinformation
Group 7 (I x E x S x M)
Experimental message: Individual x Effectiveness x Storytelling x Misinformation
Group 8 (O x E x S x M)
Experimental message: Organization x Effectiveness x Storytelling x Misinformation
Group 9 (I x S x D x F)
Experimental message: Individual x Safety x Scientific data x Factual
Group 10 (O x S x D x F)
Experimental message: Organization x Safety x Scientific data x Factual
Group 11 (I x E x D x F)
Experimental message: Individual x Effectiveness x Scientific data x Factual
Group 12 (O x E x D x F)
Experimental message: Organization x Effectiveness x Scientific data x Factual
Group 13 (I x S x D x M)
Experimental message: Individual x Safety x Scientific data x Misinformation
Group 14 (O x S x D x M)
Experimental message: Organization x Safety x Scientific data x Misinformation
Group 15 (I x E x D x M)
Experimental message: Individual x Effectiveness x Scientific data x Misinformation
Group 16 (O x E x D x M)
Experimental message: Organization x Effectiveness x Scientific data x Misinformation
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Caregivers with daughters who have already received two or more HPV vaccines.
20 Years
FEMALE
Yes
Sponsors
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London School of Hygiene and Tropical Medicine
OTHER
Nagasaki University
OTHER
The University of Hong Kong
OTHER
Responsible Party
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Principal Investigators
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Leesa Lin, PhD
Role: PRINCIPAL_INVESTIGATOR
London School of Hygiene and Tropical Medicine
Locations
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London School of Hygiene and Tropical Medicine
London, , United Kingdom
Countries
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References
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Kobayashi K, Masuda K, Wu JT, Lin L. Impact of digital communication message on HPV vaccine decision-making among Japanese mothers: A randomized controlled trial. Vaccine. 2025 Aug 13;61:127327. doi: 10.1016/j.vaccine.2025.127327. Epub 2025 Jun 3.
Other Identifiers
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UW23139
Identifier Type: -
Identifier Source: org_study_id
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