Cardiac Interventional ICE Imaging Trial

NCT ID: NCT06344494

Last Updated: 2024-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

130 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-31

Study Completion Date

2026-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The INTELICE trial is a prospective, multicenter, 1:1 randomized controlled non-inferiority study. It aims to compare a novel intracardiac echography (ICE) catheter and combined ultrasound system with existing commercial ones. The evaluation will be conducted on patients undergoing planned intracardiac interventional process.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This randomized controlled trial will enroll adult patients undergoing cardiac interventions, who will be randomly assigned to either the experimental device group or the control group.

The main endpoint of the INTELICE trial is the image quality rate of intracardiac echocardiography, which will be evaluated by three experienced sonographers from the core laboratory, while the operator's image quality assessment serves as a secondary endpoint. In addition, secondary endpoints include clinical success rate, technical success rate, procedure time, and evaluation for the experimental devices.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Structural Heart Diseases Atrial Septal Defect Patent Foramen Ovale Arrhythmias, Cardiac Atrial Fibrillation Supraventricular Tachycardia Valve Disease, Heart

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Experimental group

Subjects will undergo planned intracardiac interventional procedures utilizing the Arch EchoTM Intracardiac Ultrasound catheter and combined ultrasound system.

Group Type EXPERIMENTAL

Arch EchoTM Intracardiac Ultrasound catheter and ultrasound system

Intervention Type DEVICE

Novel ICE catheter and combined ultrasound system

Control group

Subjects will undergo planned intracardiac interventional procedures utilizing the SOUNDSTAR 3D Diagnostic Ultrasound catheter and ACUSON P500 system.

Group Type ACTIVE_COMPARATOR

SOUNDSTAR 3D Diagnostic Ultrasound catheter and ACUSON P500 system

Intervention Type DEVICE

Commercially available devices

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Arch EchoTM Intracardiac Ultrasound catheter and ultrasound system

Novel ICE catheter and combined ultrasound system

Intervention Type DEVICE

SOUNDSTAR 3D Diagnostic Ultrasound catheter and ACUSON P500 system

Commercially available devices

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age ≥ 18 years, ≤90 years, of any gender.
* Subjects deemed suitable for the utilization of ICE catheters during cardiac interventional procedures, as determined by investigators:

1. Requirement for ICE imaging of the heart;
2. Requirement for ICE imaging of great vessels;
3. Requirement for ICE imaging of other intracardiac devices.
* Subjects themselves or their guardians must possess the ability to comprehend the purpose of this study, demonstrate adequate compliance with the protocol, and sign the informed consent form.

Exclusion Criteria

* Anticipated vascular access (e.g., femoral vein, inferior vena cava, subclavian vein, internal jugular vein) cannot meet the procedure needs.
* PLT \<100\*109/L or INR \>1.5.
* Intracardiac blood clots or severe peripheral vascular disease (e.g., deep vein thrombosis, aneurysm, atherosclerosis).
* Sepsis, pyemia, or severe systemic infection.
* NYHA Class IV.
* History of cardiac or related cardiac areas surgery within 6 months.
* Inability to tolerate post procedure oral anticoagulants or antiplatelet drugs.
* Inability to tolerate or cooperate with the procedure.
* Pregnant or lactating women, women with a positive pregnancy test result within 7 days before enrollment.
* Participation in other clinical trials of drugs, biological agents or devices within 3 months before screening.
* Other exclusive circumstances determined by the investigators, where the subject is deemed unsuitable for enrollment.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

ICE Intelligent Healthcare Co., Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Deyong Long, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Beijing Anzhen Hospital

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Beijing Anzhen Hospital, Capital Medical University

Beijing, Bejing, China

Site Status

The First People's Hospital of Changzhou

Changzhou, Jiangsu, China

Site Status

The First Hospital Of Jilin University

Changchun, Jilin, China

Site Status

Shanghai General Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Deyong Long, MD, PhD

Role: CONTACT

64412431 ext. 0086010

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Deyong Long, MD, PhD

Role: primary

64412431 ext. 0086010

Ling Yang, MD

Role: primary

68873108 ext. 00860519

Shuyan Li, MD, PhD

Role: primary

88782222 ext. 00860431

Songwen Chen, MD, PhD

Role: primary

18017638339 ext. 0086

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

INTELICE-CTP-2401

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.