Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care
NCT ID: NCT06331676
Last Updated: 2026-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
NA
90 participants
INTERVENTIONAL
2024-06-21
2028-03-21
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
There is no cure for endometriosis. Hormonal treatments should be the first line therapy. The benefit-risk ratio of symptomatic treatment with hormone therapy varies greatly from one woman to another. The pathophysiology of endometriosis and the mechanisms of action of these treatments are still poorly understood. This may be due to the lack of an optimal experimental model for studying the disease.
The aim of this project is to develop a complex ex vivo endometrial model recapitulating the organisation and properties of the human endometrium using innovative tissue bioengineering methods. This model will make it possible to develop a pre-clinical approach that predicts individual response to different types of hormonal treatment in order to optimise therapeutic choices and provide a better understanding of the effects of these treatments.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Exposure to Persistent Organic Pollutants and Severity of Endometriosis in the ComPaRe-Endometriosis Cohort
NCT06973603
ENDOMET - Novel Diagnostic Tools and Treatments for Endometriosis
NCT01301885
Compliance and Endometriosis
NCT05619757
Quality of Life in Endometriosis - a Case Control Study
NCT02511626
Endometrioma Sclerotherapy and Ovarian Preservation
NCT06775769
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Endometriosis
Women with endometriosis who have an indication for gynaecological surgery
Tissue collection
Eutopic and ectopic endometrium biopsies, additional blood and peritoneal fluid sampling
Data collection
Questionnaire on menstrual health and history of hormone treatments for the research purpose
Control
Women with no endometrial pathology who have an indication for gynaecological surgery
Tissue collection
Eutopic and ectopic endometrium biopsies, additional blood and peritoneal fluid sampling
Data collection
Questionnaire on menstrual health and history of hormone treatments for the research purpose
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Tissue collection
Eutopic and ectopic endometrium biopsies, additional blood and peritoneal fluid sampling
Data collection
Questionnaire on menstrual health and history of hormone treatments for the research purpose
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* People aged between 18 and 50
* Person who has or has had hormonal contraceptive treatment
* A person who has given written consent
* Person diagnosed with a benign gynaecological pathology not affecting the endometrium and requiring hysterectomy, hysteroscopy or laparoscopy or with a diagnosis of endometriosis and requiring laparoscopy or hysterectomy
* Person affiliated to the french social security
Exclusion Criteria
* Breast-feeding women
* Women undergoing physiological menopause
* Anyone who has received hormonal treatment with hormones other than steroids in the three months prior to sampling
* Anyone with a non-hormonal contraceptive intrauterine device (copper coil)
* Anyone with a personal history of cancer of the breast, ovary, endometrium or cervix
* People with Lynch syndrome
* Persons under legal protection (guardianship, curatorship)
* Persons deprived of their liberty by judicial or administrative decision
* Persons with a body mass index (BMI) of less than 18.5 or more than 30
18 Years
50 Years
FEMALE
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Hospices Civils de Lyon
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Hôpital Femme Mère Enfant / GHE
Bron, , France
Hôpital de la Croix-Rousse / GHN
Lyon, , France
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2023-A02339-36
Identifier Type: OTHER
Identifier Source: secondary_id
69HCL23_1120
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.