Endocare for Pelvic-perineal Pain Related to Endometriosis Used at Home

NCT ID: NCT05172492

Last Updated: 2022-01-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-07

Study Completion Date

2022-09-30

Brief Summary

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Women with endometriosis experience recurrent pelvic-perineal pain impairing the quality of life, among other things. Endometriosis-related pain negatively impacts the sexual, family and work life.

Apart from the usual painkillers, the doctor's current therapeutic arsenal is limited to hormonal contraceptives and surgery. As endometriosis-related treatments do not currently address all of the patients' problems, developing a new, effective, non-pharmaceutical treatment would make it possible to relieve the pain of these women.

Endocare treatment consists of visual and auditory therapeutic procedures for pelvic-perineal pain in patients with endometriosis.

Moreover, as Endocare is not a pharmacological molecule but a digital therapy, it would not increase the consumption of pharmacological agents. An analgesic effect of Endocare lasting several hours on chronic pelvic-perineal pain associated with endometriosis is expected.

The effects of the treatment will be compare to a digital control also integrated in a virtual reality headset identical to the one distributing Endocare allowing to maintain the blindness to the patients and the investigator on the treatment received.

Detailed Description

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Conditions

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Endometriosis Chronic Pain Pelvic Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Endocare

Group Type EXPERIMENTAL

Endocare

Intervention Type DEVICE

Endocare will be administred through a virtual reality headseat used one to twice a day.

Digital control

Group Type ACTIVE_COMPARATOR

Digital control

Intervention Type DEVICE

Digital control will be administred through a virtual reality headseat used one to twice a day.

Interventions

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Endocare

Endocare will be administred through a virtual reality headseat used one to twice a day.

Intervention Type DEVICE

Digital control

Digital control will be administred through a virtual reality headseat used one to twice a day.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Women over 18 years of age with diagnosed endometriosis (histology, imaging, clinical symptomatology) and/or adenomyosis.
* Women with at least 2 consecutive days per month of endometriosis-related pelvic-perineal pain of moderate to severe intensity (NS ≥ 4):

* Women without amenorrhea: pain around the onset of menstruation.
* Women with amenorrhea: most intense pain of the month.

Exclusion Criteria

* Pregnant or nursing women.
* Women participating, or who have participated, in a clinical interventional study within 30 days prior to inclusion.
* Women with severe visual, auditory or cognitive impairment, color blindness, photosensitivity, epilepsy or motion sickness.
* Women whose pain is occasional and not present at each menstrual period.
* Women who have previously received virtual reality treatments.
* Women under judicial protection, guardianship, curatorship, protective mandate.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Biotrial

INDUSTRY

Sponsor Role collaborator

Lucine

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Clinique Tivoli Ducos

Bordeaux, Gironde, France

Site Status RECRUITING

Countries

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France

Facility Contacts

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Benjamin Merlot, MD

Role: primary

+33650139254

References

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Merlot B, Elie V, Perigord A, Husson Z, Jubert A, Chanavaz-Lacheray I, Dennis T, Cotty-Eslous M, Roman H. Pain Reduction With an Immersive Digital Therapeutic in Women Living With Endometriosis-Related Pelvic Pain: At-Home Self-Administered Randomized Controlled Trial. J Med Internet Res. 2023 Jun 28;25:e47869. doi: 10.2196/47869.

Reference Type DERIVED
PMID: 37260160 (View on PubMed)

Other Identifiers

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2021-A02358-33

Identifier Type: -

Identifier Source: org_study_id

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