Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa

NCT ID: NCT06324149

Last Updated: 2025-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-07

Study Completion Date

2026-04-30

Brief Summary

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Observational study. Participants of the FRASNET study (9th March 2017, Protocol No. 24/INT/2017) who were evaluated in 2016 and 2017 will be contacted to be re-evaluated with multidimensional visits as part of the present study in order to assess trajectories and biomarkers of frailty and sarcopenia. Moreover, are going to evaluate with the same multidimensional visits patients with mild cognitive impairment and dementia followed up at the Neurologic Unit of the San Raffaele Hospital.

Detailed Description

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Conditions

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Frailty Sarcopenia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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older volunteers

1250 individuals of the FRASNET study (original promoter of the study Ospedale San Raffaele, Principal Investigator Professor Paolo Manunta): older volunteers who were either robust or frail at the evaluations performed in 2016-2017)

* completion of scales and questionnaires
* venous blood sampling
* muscle ultrasound
* cardiac ultrasound
* electrocardiogram
* bioelectrical impedance analysis

completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogram; bioelectrical impedance analysis

Intervention Type DIAGNOSTIC_TEST

The sub-investigator performs a multidimentional geriatric evaluation

neurology patients

720 patients suffering from cognitive impairment and clinically followed at the Neurology Department of the San Raffaele Hospital (UniSR Prof Agosta)

* completion of scales and questionnaires
* venous blood sampling
* muscle ultrasound
* cardiac ultrasound
* electrocardiogram
* bioelectrical impedance analysis

completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogram; bioelectrical impedance analysis

Intervention Type DIAGNOSTIC_TEST

The sub-investigator performs a multidimentional geriatric evaluation

Interventions

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completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogram; bioelectrical impedance analysis

The sub-investigator performs a multidimentional geriatric evaluation

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Having participated in the FRASNET study or being a patient with mild cognitive impairment or dementia followed up at the Neurologic Unit of the San Raffaele Hospital
* Ability to sign written informed consent
* \> 18 years old

Exclusion Criteria

* Life expectancy \< 6 months
* Unwillingness to participate in the study
* Unstable clinical disease(for ex. serious acute pathologies)
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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IRCCS San Raffaele

OTHER

Sponsor Role lead

Responsible Party

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Rovere Querini Patrizia

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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San Raffaele Hospital

Milan, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Patrizia Rovere Querini, PhD, MD

Role: CONTACT

+390226433065

Sarah Damanti, PhD, MD

Role: CONTACT

+390226433065

Facility Contacts

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Patrizia Rovere Querini, PhD,MD

Role: primary

+390226433065

Sarah Damanti, PhD,MD

Role: backup

+390226436095

Other Identifiers

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AGE-IT-FRAILTY

Identifier Type: -

Identifier Source: org_study_id

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