Epidemiological Observatory on the Health Conditions of Inpatients Aged 65 or Older at the INRCA Research Hospitals

NCT ID: NCT01397682

Last Updated: 2023-10-23

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 2250 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-05-05
• Study Completion Date: 2025-05-31

Brief Summary

The goal of this research study is to collect clinical data, comprehensive geriatric assessment, risk factors, biological data and blood samples from inpatients aged 65 and older at the INRCA research hospitals (Italy). All data will be stored in a research bank and used to better clarify the mechanisms underlying the condition of "frailty" in aged patients. The database will be created on the INRCA server platform by establishing a safe HTTPS protocol.

Detailed Description

Life expectancy is continuously increasing in Italy. Aging is generally linked to adaptive modifications of organs and systems that reduce the functional reserve and increase the vulnerability to disease and addiction. This framework constitutes the condition of "frailty", which is associated to an increased risk of multiple adverse events as falls, fractures, disability, institutionalisation and death. To reduce the burden of disability and diseases affecting the quality of life of the elderly and, at the same time weighs heavily on health costs, a high level of managerial efficiency has to be achieved, planning the necessary health and care services and implementing measures to prevent disability in the fragile elderly. Indeed a strongly expanding area of gerontological and geriatric research is focusing on successful aging, that is characterised by a low probability of diseases and related disabilities, by a high level of physical and cognitive functionality and by an active social involvement in daily life. For this reason the project is based on the implementation of a validated system of comprehensive geriatric assessment able to provide detailed measures of the different possible interactions among risk factors. The study aimed at the descriptive-epidemiological collection of the health conditions of older in-patients at the different INRCA research hospitals (Italy). The data set will include personal data, information from the comprehensive geriatric assessment, clinical-care, biological and diagnostic data, collected routinely as well as ad hoc during hospitalisation. Moreover, a blood sample will be taken to performing biomarkers and genetic analyses.

Conditions

Aging; Inpatients

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: OTHER

Interventions

blood sample collection

A blood sample will be drawn within 24 hours from admission for determination of biomarkers and genetic analyses

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Aged 65 or older
• Inpatients at the different INRCA research hospital facilities (Italy)

Exclusion Criteria

• Inpatients who have not/for those the informed consent was not given

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Istituto Nazionale di Ricovero e Cura per Anziani

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

INRCA Research Hospital

Ancona, , Italy

INRCA Research Hospital

Casatenovo, , Italy

INRCA Research Hospital

Cosenza, , Italy

INRCA Research Hospital

Fermo, , Italy

Countries

Italy

References

Besdine RW, Wetle TF. Improving health for elderly people: an international health promotion and disease prevention agenda. Aging Clin Exp Res. 2010 Jun;22(3):219-30. doi: 10.1007/BF03324800.

Reference Type: BACKGROUND

PMID: 20634645 (View on PubMed)

Di Rosa M, Sabbatinelli J, Soraci L, Corsonello A, Bonfigli AR, Cherubini A, Sarzani R, Antonicelli R, Pelliccioni G, Galeazzi R, Marchegiani F, Iuorio S, Colombo D, Burattini M, Lattanzio F, Olivieri F. Neutrophil-to-lymphocyte ratio (NLR) predicts mortality in hospitalized geriatric patients independent of the admission diagnosis: a multicenter prospective cohort study. J Transl Med. 2023 Nov 21;21(1):835. doi: 10.1186/s12967-023-04717-z.

Reference Type: DERIVED

PMID: 37990223 (View on PubMed)

Corsonello A, Soraci L, Di Rosa M, Bustacchini S, Bonfigli AR, Lisa R, Liperoti R, Tettamanti M, Cherubini A, Antonicelli R, Pelliccioni G, Postacchini D, Lattanzio F. Prognostic Interplay of Functional Status and Multimorbidity Among Older Patients Discharged From Hospital. J Am Med Dir Assoc. 2022 Mar;23(3):499-506.e1. doi: 10.1016/j.jamda.2021.07.012. Epub 2021 Aug 9.

Reference Type: DERIVED

PMID: 34384766 (View on PubMed)

Gagliardi C, Corsonello A, Di Rosa M, Fabbietti P, Cherubini A, Mercante O, Mazzei B, Postacchini D, Deales A, Bustacchini S, Lattanzio F. Preadmission Functional Decline Predicts Functional Improvement Among Older Patients Admitted to Acute Care Hospital. J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1363-1369. doi: 10.1093/gerona/glx211.

Reference Type: DERIVED

PMID: 29087448 (View on PubMed)

Bustacchini S, Abbatecola AM, Bonfigli AR, Chiatti C, Corsonello A, Di Stefano G, Galeazzi R, Fabbietti P, Lisa R, Guffanti EE, Provinciali M, Lattanzio F; Report-Age study group. The Report-AGE project: a permanent epidemiological observatory to identify clinical and biological markers of health outcomes in elderly hospitalized patients in Italy. Aging Clin Exp Res. 2015 Dec;27(6):893-901. doi: 10.1007/s40520-015-0350-3. Epub 2015 Mar 26.

Reference Type: DERIVED

PMID: 25809054 (View on PubMed)

Other Identifiers

INRCA-01-2011

Identifier Type: -

Identifier Source: org_study_id