Non-Invasive Pressure Monitor for Neonates & Infants at Risk of Developing Hydrocephalus

NCT ID: NCT06310213

Last Updated: 2025-10-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-24

Study Completion Date

2029-01-01

Brief Summary

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The goal of this clinical trial is to test a modified smart soft contact lens in neonates and infants at risk of developing hydrocephalus. The main questions it aims to answer are:

* Can the device distinguish between intracranial pressure variations in neonates and infants diagnosed with hydrocephalus and those without
* Can the device compare pressure dynamics between pre- and post-operative periods in neonates and infants who undergo surgical treatments Participants will undergo standard of care evaluations for hydrocephalus (anterior fontanelle assessment and head circumference measurement) and wear the device during standard of care evaluation; pre- and post- ventricular reservoir taps, as applicable; and/or pre- and post-operatively, as applicable.

Detailed Description

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Conditions

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Hydrocephalus in Infants

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SEQUENTIAL

Aim 1: Comparison of neonates and infants with hydrocephalus and without Aim 2: Using smart soft contact lens (SSCL) for pre- and post-operative measurements on neonates and/or infants managed operatively (shunt placement) Aim 3: Direct validation by comparing SSCL to external ventricular drain (EVD) intracranial pressure (ICP) monitoring Aim 4: Using SSCL for pre- and post- reservoir tap measurements on neonates and/or infants managed operatively (reservoir placement) Aim 1: 10 patients per arm, two arms Aim 2: 5-10 patients, one arm Aim 3: 5-10 patients, one arm Aim 4: 5-10 patients, one arm
Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Aim 1 Control

Intervention at single time point not to interfere with standard of care procedures

Group Type ACTIVE_COMPARATOR

Non-Invasive Pressure Monitor

Intervention Type DEVICE

Modified smart soft contact lens and cap with reader coil

Aim 1 Hydrocephalus

Intervention at single time point during standard of care hydrocephalus evaluation (anterior fontanelle assessment and measurement of head circumference), unless further assigned to supplemental arm following standard of care surgical procedure

Group Type EXPERIMENTAL

Non-Invasive Pressure Monitor

Intervention Type DEVICE

Modified smart soft contact lens and cap with reader coil

Aim 2 Hydrocephalus, Shunt surgery

Intervention pre- and post-operatively

Group Type EXPERIMENTAL

Non-Invasive Pressure Monitor

Intervention Type DEVICE

Modified smart soft contact lens and cap with reader coil

Aim 3 Hydrocephalus, EVD ICP monitor

Intervention during standard of care monitoring of EVD ICP reading(s)/hydrocephalus evaluation (anterior fontanelle assessment and measurement of head circumference)

Group Type EXPERIMENTAL

Non-Invasive Pressure Monitor

Intervention Type DEVICE

Modified smart soft contact lens and cap with reader coil

Aim 4 Hydrocephalus, Reservoir surgery

Intervention pre- and post- ventricular reservoir tap(s)

Group Type EXPERIMENTAL

Non-Invasive Pressure Monitor

Intervention Type DEVICE

Modified smart soft contact lens and cap with reader coil

Interventions

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Non-Invasive Pressure Monitor

Modified smart soft contact lens and cap with reader coil

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Being monitored for hydrocephalus, or healthy controls

Exclusion Criteria

* Known hypersensitivity to materials used in the contact lens and/or adhesive
* Open/closed wounds at/near the anterior fontanelle
* Anterior fontanelle is closed
* Other conditions deemed relevant by the medical team
Minimum Eligible Age

0 Months

Maximum Eligible Age

12 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Indiana University

OTHER

Sponsor Role lead

Responsible Party

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Jignesh Tailor

Assistant Professor of Neurological Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jignesh Tailor

Role: PRINCIPAL_INVESTIGATOR

Indiana University

Locations

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Riley Hospital for Children

Indianapolis, Indiana, United States

Site Status

Countries

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United States

Other Identifiers

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17368

Identifier Type: -

Identifier Source: org_study_id

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