Fully Hybrid 18F-PSMA PET/MRI as One-stop Approach for the Diagnosis of Clinically Significant Prostate Cancer.

NCT ID: NCT06305390

Last Updated: 2024-10-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

167 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-04

Study Completion Date

2026-07-31

Brief Summary

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This project aims to evaluate the role of fully hybrid PET/MRI with 18FPSMA and multiparametric MR imaging (mpMRI) as one-stop approach for the diagnosis of clinically significant prostate cancer (csPCa).

Our main hypothesis is that adding 18F-PSMA PET to mpMRI prior to biopsy, will reduce the number of false negative findings, while at the same time, allowing also to reduce the number of unnecessary prostate biopsies in patients with low-risk, clinically indolent PCa.

Detailed Description

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Conditions

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Clinical Suspicion of Prostate Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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single arm

PET/MRI

Intervention Type DIAGNOSTIC_TEST

18F-PSMA PET/MRI

Interventions

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PET/MRI

18F-PSMA PET/MRI

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Men at least 18 years of age referred with clinical suspicion of prostate cancer candidate for prostate biopsy
2. Feasibility to undergo all procedures listed in protocol
3. Ability to provide written informed consent

Exclusion Criteria

1. Prior diagnosis of prostate cancer
2. Contraindication to MRI (e.g. claustrophobia, pacemaker, estimated GFR lower or equal to 50mls/min)
3. Contraindication to prostate biopsy
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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IRCCS San Raffaele

OTHER

Sponsor Role lead

Responsible Party

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Chiti Arturo

PI

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Arturo Chiti, MD

Role: STUDY_DIRECTOR

IRCCS Ospedale San Raffaele

Locations

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U.O. of Nuclear Medicine, ,Ospedale San Raffaele

Milan, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Maria Picchio, MD

Role: CONTACT

02-26436117

Rachele Di Donato, PhD

Role: CONTACT

02-26433639

Facility Contacts

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Maria Picchio, MD

Role: primary

02-26436117

Other Identifiers

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2022-003905-31

Identifier Type: -

Identifier Source: org_study_id

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