Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors
NCT ID: NCT06302660
Last Updated: 2025-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
ACTIVE_NOT_RECRUITING
100 participants
OBSERVATIONAL
2022-03-09
2025-12-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
* Study the changes in gut bacteria by examining saliva, stool and blood.
* Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria.
* Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors.
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires.
Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Metabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment Methods of Treatment Response for Precision Therapy
NCT03223662
IMaC - Immune Pathways in Oesophagogastric Cancer
NCT06057220
Non-invasive Testing for Early oEesophageal Cancer and Dysplasia
NCT04001478
Determination of the Role of Microarray for Prognosis and Prediction to Chemotherapy Sensitivity in Patients With Operable, Locally Advanced and Metastatic Oesophageal Cancer
NCT00220077
Phase I/II Study of TPF as First-line Chemotherapy in Patients With Metastatic Esophageal Cancer.
NCT00209690
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
CASE_CONTROL
CROSS_SECTIONAL
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Oesophageal adenocarcinoma survivors
100 disease free survivors who underwent multimodality treatment for oesophageal adenocarcinoma and are \>1 year post oesophagectomy
Breath test
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath.
Saliva sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva.
Blood sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood.
Urine sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine.
Stool sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool.
Health-related Quality of life questionnaires
Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Breath test
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath.
Saliva sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva.
Blood sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood.
Urine sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine.
Stool sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool.
Health-related Quality of life questionnaires
Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Patients who underwent oesophagectomy for oesophageal adenocarcinoma with curative intent
* Disease free patients (CT with no evidence of recurrence within last 6 months or more than 5 years post oesophageal resection)
* Patients more than 1 year post oesophageal resection
Exclusion Criteria
* Patients with evidence of disease recurrence
* Patients who are unable or unwilling to provide informed written consent
* Patients who have received antibiotic therapy within the last 4 weeks
18 Years
90 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Imperial College Healthcare NHS Trust
OTHER
West Hertfordshire Teaching Hospitals NHS Trust
UNKNOWN
Barking, Havering and Redbridge University Hospitals NHS Trust
OTHER
Imperial College London
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Barking, Havering and Redbridge University Hospitals NHS Trust
London, , United Kingdom
Imperial College Healthcare NHS Trust
London, , United Kingdom
West Hertfordshire NHS Teaching Hospitals
London, , United Kingdom
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
22/LO/0169
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.