Genetic and Environmental Risk Factors Related to Esophageal Cancer
NCT ID: NCT01035398
Last Updated: 2024-11-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
OBSERVATIONAL
2000-04-30
2026-09-30
Brief Summary
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PURPOSE: This clinical trial is studying genetic and environmental risk factors related to esophageal cancer.
Detailed Description
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* Examine the role of several genetically-determined factors in combination with cigarette smoking and diet in the etiology and prevention of esophageal cancer.
* Identify polymorphisms in metabolizing enzymes (e.g., phase I or II metabolism \[GSTM1, GSTT1,CYP1A1, CYP3A5, mEH, NQO1, GSTP1\], DNA repair \[XRCC1, ERCC2\], free-radical formation \[MPO, MnSOD\], inflammatory genes \[ IL1-beta\], metastatic potential \[MMP1\], and cell cycle or tumor suppression \[p21, p53\]) and related path genes of susceptibility for esophageal cancer.
OUTLINE: Blood and tumor tissue samples are collected. DNA purified from these samples is analyzed using DNA-based assays to determine polymorphisms in various related gene pathways.
Patients complete questionnaires concerning environmental, smoking and diet habits.
PROJECTED ACCRUAL: A total of 1,000 tissue samples from patients and healthy participants (750 patients and 250 healthy participants) will be accrued for this study.
Conditions
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Eligibility Criteria
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Inclusion Criteria
* Meets 1 of the following criteria:
* Diagnosis of esophageal cancer (patient)
* Newly diagnosed disease
* Receiving care at Massachusetts General Hospital, Thoracic Oncology Center
* Friend or spouse of patient (healthy participants)
PATIENT CHARACTERISTICS:
* No concurrent psychiatric incapacity or dementia
PRIOR CONCURRENT THERAPY:
* Not specified
18 Years
100 Years
ALL
Yes
Sponsors
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National Cancer Institute (NCI)
NIH
Massachusetts General Hospital
OTHER
Responsible Party
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David Christopher Christiani
Pulmonary Associate
Principal Investigators
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David C. Christiani, MD
Role: PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
Harvard School of Public Health
Boston, Massachusetts, United States
Countries
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Other Identifiers
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MGH-1999-P-010178/23
Identifier Type: OTHER
Identifier Source: secondary_id
CDR0000450143
Identifier Type: -
Identifier Source: org_study_id