Characterization of Exosomes Platelets-released

NCT ID: NCT06298682

Last Updated: 2024-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

175 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-08

Study Completion Date

2027-07-07

Brief Summary

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Extracellular vesicles (EVs) play a key role in cell-to-cell communication. They are small vesicles that contain rich molecular cargo. Recently, they have been proposed as biomarkers for clinical diagnostics. EVs include three classes: small EVs (exosomes), large EVs (microparticles), and apoptotic bodies. Platelet-derived EVs (PEVs) are the most abundant class in human blood and can actively participate in numerous physiological and pathological processes. The information about the role of platelet exosomes in cardiovascular disease and the effect of antiplatelet agents on their release and content is very limited.

Detailed Description

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This study is a multicentre, observational. We plan to enrol 54 subjects from Centro Cardiologico Monzino IRCCS, and 121 buffy coat related to 121 subjects from Centro Trasfusionale Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. biographical and anthropomorphic data will be recorded, a fasting blood venous sample (from ante-cubital vein) will be collected for the haematochemical analyses and for research samples.

Conditions

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Platelet Thrombus

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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subjects without known pathologies

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* subjects without known pathologies

Exclusion Criteria

* individuals with gastrointestinal diseases,
* individuals with history of hepatic diseases,
* individuals with history of urogenital diseases,
* individuals with history of hematological diseases,
* individuals with history of immunological diseases,
* individuals with history of renal diseases,
* individuals with history of metabolic diseases
* individuals with history of respiratory diseases
* individuals with history of cancer
* individuals with history of cardiovascular disease
* individuals having permanent organ damage
* individuals with major trauma in the last 6 months prior to enrollment
* individuals with surgery in the last 6 months prior to enrollment
* individuals taking medication in the 15 days prior to enrolment.
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

OTHER

Sponsor Role collaborator

Centro Cardiologico Monzino

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Silvia S Barbieri, PhD

Role: CONTACT

0258002021

Facility Contacts

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Daniele Prati

Role: primary

Other Identifiers

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CCM1421

Identifier Type: -

Identifier Source: org_study_id

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