Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation

NCT ID: NCT02594345

Last Updated: 2016-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2015-12-31

Brief Summary

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This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.

Detailed Description

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The blood of 25 healthy volunteers will be exposed to exosomes derived from red blood cell units. The effects on coagulation and platelet function will be measured using thromboelastometry (ROTEMĀ®) and FACS analysis.

Conditions

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Blood Coagulation Platelet Function

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Intervention group

Group Type EXPERIMENTAL

in vitro study

Intervention Type OTHER

Exosomes will be mixed with healthy volunteers' blood in vitro

Interventions

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in vitro study

Exosomes will be mixed with healthy volunteers' blood in vitro

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* healthy volunteers

Exclusion Criteria

* pregnancy
* drug use
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Johann Wolfgang Goethe University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Dr Dania Fischer

Research associate

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dania P Fischer, M.D.

Role: PRINCIPAL_INVESTIGATOR

Goethe University

Locations

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University Hospital Frankfurt

Frankfurt am Main, Hesse, Germany

Site Status

Countries

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Germany

Other Identifiers

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ExoRBC

Identifier Type: -

Identifier Source: org_study_id

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