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Circulating Endothelial Progenitor Cells and Aortic Aneurysm

NCT ID: NCT01918982

Last Updated: 2013-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-10-31

Study Completion Date

2016-05-31

Brief Summary

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We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.

Detailed Description

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Circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level. 40 patients followed for known aortic aneurysm \>30mm and \<50mm will be followed up every 6 months during 2 years. Each 6 months they will have a consultation by their physiologist with an echo or a CT-scan. At the same time, a 10ML blood sample will be taken to assess the circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.

Conditions

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- Aortic Aneurysm

Keywords

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Aortic aneurysm circulating endothelial progenitor cells

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Aortic aneurysm

Patients with aortic aneurysm \>30mm and \< 50mm

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Aortic aneurysm size \>30mm and \> 50mm

Exclusion Criteria

* Infectious disease
* Inflammatory disease
* Liver insuffisency
* Cancer evolutive
* Pregnant women
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hopital Jean Minjoz

OTHER

Sponsor Role lead

Responsible Party

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Prof. Sidney Chocron

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sidney Chocron, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Université de Franche-comté. France

Andrea Perrotti, MD

Role: PRINCIPAL_INVESTIGATOR

Université de Franche-Comté. France

Simon Rinckenbach, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Université de Franche-Comté. France

Siamak Davani, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Université de Franche-Comté. France

Central Contacts

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Sidney Chocron

Role: CONTACT

Phone: +33381533121

Email: [email protected]

References

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Parietti E, Pallandre JR, Deschaseaux F, Aupecle B, Durst C, Kantelip JP, Chocron S, Davani S. Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1alpha are associated with ascending aorta aneurysm size. Eur J Cardiothorac Surg. 2011 Jul;40(1):e6-12. doi: 10.1016/j.ejcts.2011.02.065. Epub 2011 Apr 9.

Reference Type BACKGROUND
PMID: 21481600 (View on PubMed)

Other Identifiers

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147/362

Identifier Type: -

Identifier Source: org_study_id