Effect of Continuing Versus Holding Metformin During Hospitalizations.
NCT ID: NCT06296836
Last Updated: 2025-02-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
300 participants
INTERVENTIONAL
2025-01-21
2026-06-30
Brief Summary
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Detailed Description
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The objectives of this study are to determine how holding versus continuing metformin during hospitalization to an internal medicine service affects the incidences of lactic acidosis, mean anion gap, mean glucose levels, low and very high blood sugars, GI effects after discharge, lack of continuation of metformin upon discharge, mean glucose levels, lengths of stay, and 30-day mortality.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Metformin continuation
Continuation of home metformin regimen during hospitalization to an internal medicine service
Metformin
Continuation of home metformin
Metformin discontinuation
Holding home metformin regimen during hospitalization to an internal medicine service
No interventions assigned to this group
Interventions
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Metformin
Continuation of home metformin
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Admitted to an internal medicine service.
* On Metformin prior to admission.
Exclusion Criteria
* eGFR \< 30 ml/min/1.73 m2
* Dialysis
* Current Acidosis (pH \< 7.35) including diabetic ketoacidosis
* Child-Turcotte-Pugh class C hepatic cirrhosis
* Acute Decompensated Heart Failure
* Cognitively impaired and/or unable to consent
* Lack of or unwillingness to share contact information
* Pregnant women
18 Years
110 Years
ALL
No
Sponsors
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University of Illinois at Chicago
OTHER
Responsible Party
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Locations
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University of Illinois at Chicago
Chicago, Illinois, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024-001
Identifier Type: -
Identifier Source: org_study_id
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